Universität zu Köln

Hartmann, Sylvia, Eichenauer, Dennis A., Pluetschow, Annette, Mottok, Anja ORCID: 0000-0003-3125-0494, Bob, Roshanak, Koch, Karoline, Bernd, Heinz-Wolfram, Cogliatti, Sergio, Hummel, Michael, Feller, Alfred C., Ott, German, Moeller, Peter, Rosenwald, Andreas, Stein, Harald, Hansmann, Martin-Leo, Engert, Andreas and Klapper, Wolfram (2013). The prognostic impact of variant histology in nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG). Blood, 122 (26). S. 4246 - 4253. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) accounts for approximately 5% of all Hodgkin lymphoma cases. The aim of this study was to evaluate the prognostic implication of histopathologic NLPHL variants. Biopsies of 423 NLPHL patients treated within 9 prospective clinical trials performed by the German Hodgkin Study Group were classified as tumor cell-rich cases (n = 10), typical NLPHL (n = 308), or histopathologic variants (n = 105). Histopathologic variants were characterized by the presence of lymphoma cells outside the B-cell nodules or B-cell depletion of the micro-environment. Compared with typical NLPHL, histopathologic variants were associated with advanced disease (29.5% vs 14.6%, P = .0012) and a higher relapse rate (18.1% vs 6.5% at 5 years, P = .0009). Variant histology represented an independent prognostic factor (odds ratio = 2.955) in a multivariate model of progression/relapse. A prognostic score, including the risk factors variant histopathologic growth pattern, low serum albumin, and male gender, was derived from this model and allowed the definition of 3 distinct risk groups. NLPHL patients presenting with histopathologic variants have a poorer outcome compared with those showing typical histology. The newly developed prognostic score combining histologic and clinical features allows allocating NLPHL patients to defined risk groups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hartmann, Sylvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichenauer, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pluetschow, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Mottok, Anja UNSPECIFIED orcid.org/0000-0003-3125-0494 UNSPECIFIED Bob, Roshanak UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernd, Heinz-Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Cogliatti, Sergio UNSPECIFIED UNSPECIFIED UNSPECIFIED Hummel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Feller, Alfred C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, German UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenwald, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansmann, Martin-Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapper, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-469973
DOI:	10.1182/blood-2013-07-515825
Journal or Publication Title:	Blood
Volume:	122
Number:	26
Page Range:	S. 4246 - 4253
Date:	2013
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVOLVED-FIELD RADIOTHERAPY; REED-STERNBERG CELLS; FOLLICULAR LYMPHOMA; GERMINAL-CENTERS; FINAL ANALYSIS; DISEASE; STAGE; RITUXIMAB; PHASE-2; CHEMOTHERAPY Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/46997