Universität zu Köln

Pietsch, Markus, Wodtke, Robert ORCID: 0000-0001-7462-7111, Pietzsch, Jens ORCID: 0000-0002-1610-1493 and Loeser, Reik (2013). Tissue transglutaminase: An emerging target for therapy and imaging. Bioorg. Med. Chem. Lett., 23 (24). S. 6528 - 6544. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1464-3405

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Abstract

Tissue transglutaminase (transglutaminase 2) is a multifunctional enzyme with many interesting properties resulting in versatile roles in both physiology and pathophysiology. Herein, the particular involvement of the enzyme in human diseases will be outlined with special emphasis on its role in cancer and in tissue interactions with biomaterials. Despite recent progress in unraveling the different cellular functions of transglutaminase 2, several questions remain. Transglutaminase 2 features in both confirmed and some still ambiguous roles within pathological conditions, raising interest in developing inhibitors and imaging probes which target this enzyme. One important prerequisite for identifying and characterizing such molecular tools are reliable assay methods to measure the enzymatic activity. This digest Letter will provide clarification about the various assay methods described to date, accompanied by a discussion of recent progress in the development of inhibitors and imaging probes targeting transglutaminase 2. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pietsch, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wodtke, Robert UNSPECIFIED orcid.org/0000-0001-7462-7111 UNSPECIFIED Pietzsch, Jens UNSPECIFIED orcid.org/0000-0002-1610-1493 UNSPECIFIED Loeser, Reik UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470060
DOI:	10.1016/j.bmcl.2013.09.060
Journal or Publication Title:	Bioorg. Med. Chem. Lett.
Volume:	23
Number:	24
Page Range:	S. 6528 - 6544
Date:	2013
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1464-3405
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COAGULATION-FACTOR-XIII; PIG LIVER TRANSGLUTAMINASE; NF-KAPPA-B; SENSITIVE FLUOROMETRIC ASSAY; INDEPENDENT CELL-ADHESION; GLUTEN PEPTIDE ANALOGS; PROTEIN CROSS-LINKING; HEPARIN-BINDING-SITE; ACTIVE-SITE; IRREVERSIBLE INHIBITORS Multiple languages Chemistry, Medicinal; Chemistry, Organic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47006