Universität zu Köln

Weiss, Peter H. ORCID: 0000-0002-5230-9080, Achilles, Elisabeth I. S., Moos, Katharina, Hesse, Maike D., Sparing, Roland and Fink, Gereon R. ORCID: 0000-0002-8230-1856 (2013). Transcranial Direct Current Stimulation (tDCS) of Left Parietal Cortex Facilitates Gesture Processing in Healthy Subjects. J. Neurosci., 33 (49). S. 19205 - 19212. WASHINGTON: SOC NEUROSCIENCE. ISSN 0270-6474

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Abstract

Gesture processing deficits constitute a key symptom of apraxia, a disorder of motor cognition frequently observed after left-hemispheric stroke. The clinical relevance of apraxia stands in stark contrast to the paucity of therapeutic options available. Transcranial direct current stimulation (tDCS) is a promising tool for modulating disturbed network function after stroke. Here, we investigate the effect of parietal tDCS on gesture processing in healthy human subjects. Neuropsychological and imaging studies suggest that the imitation and matching of hand gestures involve the left inferior parietal lobe (IPL). Using neuronavigation based on cytoarchitectonically defined anatomical probability maps, tDCS was applied over left IPL-areas PF, PFm, or PG in healthy participants (n = 26). Before and after tDCS, subjects performed a gesture matching task and a person discrimination task for control. Changes in error rates and reaction times were analyzed for the effects of anodal and cathodal tDCS (compared with sham tDCS). Matching of hand gestures was specifically facilitated by anodal tDCS applied over the cytoarchitectonically defined IPL-area PFm, whereas tDCS over IPL-areas PF and PG did not elucidate significant effects. Taking into account tDCS electrode size and the central position of area PFm within IPL, it can be assumed that the observed effect is rather the result of a combined stimulation of the supramarginal and angular gyrus than an isolated PFm stimulation. Our data confirm the pivotal role of the left IPL in gesture processing. Furthermore, anatomically guided tDCS of the left IPL may constitute a promising approach to neurorehabilitation of apraxic patients with gesture processing deficits.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weiss, Peter H. UNSPECIFIED orcid.org/0000-0002-5230-9080 UNSPECIFIED Achilles, Elisabeth I. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moos, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hesse, Maike D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sparing, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470300
DOI:	10.1523/JNEUROSCI.4714-12.2013
Journal or Publication Title:	J. Neurosci.
Volume:	33
Number:	49
Page Range:	S. 19205 - 19212
Date:	2013
Publisher:	SOC NEUROSCIENCE
Place of Publication:	WASHINGTON
ISSN:	0270-6474
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; NEUROLOGICAL PRINCIPLES; NEURAL REPRESENTATIONS; MEANINGLESS GESTURES; IDEOMOTOR APRAXIA; BRAIN-STIMULATION; RIGHT HEMISPHERES; IMITATION; REHABILITATION; PARCELLATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47030