Universität zu Köln

Farahmand, P., Marin, F., Hawkins, F., Moericke, R., Ringe, J. D., Glueer, C. -C., Papaioannou, N., Minisola, S., Martinez, G., Nolla, J. M., Niedhart, C., Guanabens, N., Nuti, R., Martin-Mola, E., Thomasius, F., Pena, J., Graeff, C., Kapetanos, G., Petto, H., Gentzel, A., Reisinger, A. and Zysset, P. K. (2013). Early changes in biochemical markers of bone formation during teriparatide therapy correlate with improvements in vertebral strength in men with glucocorticoid-induced osteoporosis. Osteoporosis Int., 24 (12). S. 2971 - 2982. LONDON: SPRINGER LONDON LTD. ISSN 1433-2965

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Abstract

Changes of the bone formation marker PINP correlated positively with improvements in vertebral strength in men with glucocorticoid-induced osteoporosis (GIO) who received 18-month treatment with teriparatide, but not with risedronate. These results support the use of PINP as a surrogate marker of bone strength in GIO patients treated with teriparatide. Introduction To investigate the correlations between biochemical markers of bone turnover and vertebral strength estimated by finite element analysis (FEA) in men with GIO. Methods A total of 92 men with GIO were included in an 18-month, randomized, open-label trial of teriparatide (20 mu g/day, n=45) and risedronate (35 mg/week, n=47). High-resolution quantitative computed tomography images of the 12th thoracic vertebra obtained at baseline, 6 and 18 months were converted into digital nonlinear FE models and subjected to anterior bending, axial compression and torsion. Stiffness and strength were computed for each model and loading mode. Serum biochemical markers of bone formation (amino-terminal-propeptide of type I collagen [PINP]) and bone resorption (type I collagen cross-linked C-telopeptide degradation fragments [CTx]) were measured at baseline, 3 months, 6 months and 18 months. A mixed-model of repeated measures analysed changes from baseline and between-group differences. Spearman correlations assessed the relationship between changes from baseline of bone markers with FEA variables. Results PINP and CTx levels increased in the teriparatide group and decreased in the risedronate group. FEA-derived parameters increased in both groups, but were significantly higher at 18 months in the teriparatide group. Significant positive correlations were found between changes from baseline of PINP at 3, 6 and 18 months with changes in FE strength in the teriparatide-treated group, but not in the risedronate group. Conclusions Positive correlations between changes in a biochemical marker of bone formation and improvement of biomechanical properties support the use of PINP as a surrogate marker of bone strength in teriparatide-treated GIO patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Farahmand, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marin, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hawkins, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moericke, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ringe, J. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Glueer, C. -C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papaioannou, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Minisola, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martinez, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nolla, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niedhart, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guanabens, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nuti, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin-Mola, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomasius, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pena, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graeff, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kapetanos, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Petto, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gentzel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reisinger, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zysset, P. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470644
DOI:	10.1007/s00198-013-2379-5
Journal or Publication Title:	Osteoporosis Int.
Volume:	24
Number:	12
Page Range:	S. 2971 - 2982
Date:	2013
Publisher:	SPRINGER LONDON LTD
Place of Publication:	LONDON
ISSN:	1433-2965
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUANTITATIVE COMPUTED-TOMOGRAPHY; FINITE-ELEMENT-ANALYSIS; MINERAL DENSITY RESPONSE; TURNOVER MARKERS; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; FRACTURE RISK; RALOXIFENE TREATMENT; FEMORAL STRENGTH; TERM CHANGES Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47064