Universität zu Köln

Kamiyama, Takuya, Ozer, Merve Sinem, Otth, Elisabeth, Deska, Jan ORCID: 0000-0003-4622-2365 and Cvengros, Jan (2013). Modular Synthesis of Optically Active Troger's Base Analogues. ChemPlusChem, 78 (12). S. 1510 - 1517. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 2192-6506

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Abstract

For the first time, enantioselective catalysis was applied for the preparation of Troger's base derivatives affording N-stereogenic building blocks not only in excellent enantiomeric purity but also in an easily scalable fashion. Enzymatic kinetic resolution proved efficient to yield functionalized Troger's bases, which can be subsequently modified by various chemical methods without any erosion of stereogenic information. In concert with a preparatively convenient protocol for the synthesis of the racemic substrates from commercially available anilines, a highly practicable and flexible route towards a wide range of enantiopure Troger's base analogues is provided.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kamiyama, Takuya UNSPECIFIED UNSPECIFIED UNSPECIFIED Ozer, Merve Sinem UNSPECIFIED UNSPECIFIED UNSPECIFIED Otth, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Deska, Jan UNSPECIFIED orcid.org/0000-0003-4622-2365 UNSPECIFIED Cvengros, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470814
DOI:	10.1002/cplu.201300295
Journal or Publication Title:	ChemPlusChem
Volume:	78
Number:	12
Page Range:	S. 1510 - 1517
Date:	2013
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	2192-6506
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language KINETIC RESOLUTION; ASYMMETRIC-SYNTHESIS; CONFIGURATION; ENANTIOMERS; CHEMISTRY Multiple languages Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47081