Universität zu Köln

Mathys, Christian, Aissa, Joel, Hoerste, Gerd Meyer Zu, Reichelt, Dorothea C., Antoch, Gerald, Turowski, Bernd, Hartung, Hans-Peter, Sheikh, Kazim A. and Lehmann, Helmar C. (2013). PERIPHERAL NEUROPATHY: ASSESSMENT OF PROXIMAL NERVE INTEGRITY BY DIFFUSION TENSOR IMAGING. Muscle Nerve, 48 (6). S. 889 - 897. HOBOKEN: WILEY-BLACKWELL. ISSN 1097-4598

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Abstract

Introduction: We investigated the utility of diffusion tensor imaging (DTI) for detecting neuropathic changes in proximal nerve segments in patients with peripheral neuropathy. Methods: Twenty-one individuals with (n=11) and without (n=10) peripheral neuropathy underwent DTI of a defined sciatic nerve segment. Patients and controls were evaluated by clinical examination and nerve conduction studies at baseline and 6 months after the initial DTI scan. Results: The mean fractional anisotropy (FA) value was significantly lower in sciatic nerves from patients with peripheral neuropathy as compared with controls. Sciatic nerve FA values correlated with clinical disability scores and electrophysiological parameters of axonal damage at baseline and 6 months after MRI scan. Conclusions: DTI-derived FA values are a sensitive measure to discriminate healthy from functionally impaired human sciatic nerve segments. DTI of proximal nerve segments may be useful for estimating the proximal axonal degeneration burden in patients with peripheral neuropathies. Muscle Nerve48: 889-896, 2013

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mathys, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Aissa, Joel UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoerste, Gerd Meyer Zu UNSPECIFIED UNSPECIFIED UNSPECIFIED Reichelt, Dorothea C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antoch, Gerald UNSPECIFIED UNSPECIFIED UNSPECIFIED Turowski, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartung, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Sheikh, Kazim A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470849
DOI:	10.1002/mus.23855
Journal or Publication Title:	Muscle Nerve
Volume:	48
Number:	6
Page Range:	S. 889 - 897
Date:	2013
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1097-4598
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VIVO 3-DIMENSIONAL RECONSTRUCTION; CLINICAL-RESEARCH STANDARDS; CARPAL-TUNNEL-SYNDROME; MEDIAN NERVE; RETINAL ISCHEMIA; WHITE-MATTER; TRACTOGRAPHY; MRI; DEGENERATION; REGENERATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47084