Universität zu Köln

van Eijndhoven, Philip ORCID: 0000-0003-3474-4326, van Wingen, Guido ORCID: 0000-0003-3076-5891, Katzenbauer, Maartje, Groen, Wouter, Tepest, Ralf ORCID: 0000-0002-2421-2652, Fernandez, Guillen ORCID: 0000-0002-5522-0604, Buitelaar, Jan and Tendolkar, Indira (2013). Paralimbic Cortical Thickness in First-Episode Depression: Evidence for Trait-Related Differences in Mood Regulation. Am. J. Psychiat., 170 (12). S. 1477 - 1487. ARLINGTON: AMER PSYCHIATRIC PUBLISHING, INC. ISSN 1535-7228

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Abstract

Objective: Impaired mood regulation is a key deficit of major depressive disorder that is primarily mediated by an interaction between the paralimbic cortex (i.e., orbitofrontal, cingulate, insular, parahippocampal, and temporopolar cortices) and limbic regions. The authors investigated whether depressed patients and healthy comparison subjects have differences in cortical thickness in the paralimbic cortex and whether potential differences are evident only during a depressive state or are trait related. Method: Forty patients with a first episode of major depressive disorder participated: 20 medication-naive currently depressed patients and 20 medication-free recovered patients. The patients and 31 matched healthy comparison subjects underwent structural magnetic resonance imaging. Group differences in mean cortical thickness of the paralimbic cortex were measured by using FreeSurfer software, with adjustment for age, sex, and intracranial volume, and subgroup analyses were performed to assess state and trait effects. Results: The medial orbitofrontal cortex was thinner in the depressed patients than in the comparison subjects. Greater thickness was present in the temporal pole and the caudal anterior and posterior cingulate cortex. All changes were trait related. Conclusions: The data provide evidence that even early in the course of depression brain regions involved in mood regulation show trait-related differences in cortical thickness.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van Eijndhoven, Philip UNSPECIFIED orcid.org/0000-0003-3474-4326 UNSPECIFIED van Wingen, Guido UNSPECIFIED orcid.org/0000-0003-3076-5891 UNSPECIFIED Katzenbauer, Maartje UNSPECIFIED UNSPECIFIED UNSPECIFIED Groen, Wouter UNSPECIFIED UNSPECIFIED UNSPECIFIED Tepest, Ralf UNSPECIFIED orcid.org/0000-0002-2421-2652 UNSPECIFIED Fernandez, Guillen UNSPECIFIED orcid.org/0000-0002-5522-0604 UNSPECIFIED Buitelaar, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Tendolkar, Indira UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-470935
DOI:	10.1176/appi.ajp.2013.12121504
Journal or Publication Title:	Am. J. Psychiat.
Volume:	170
Number:	12
Page Range:	S. 1477 - 1487
Date:	2013
Publisher:	AMER PSYCHIATRIC PUBLISHING, INC
Place of Publication:	ARLINGTON
ISSN:	1535-7228
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VOXEL-BASED MORPHOMETRY; ANTERIOR CINGULATE CORTEX; BIPOLAR-DISORDER; MAJOR DEPRESSION; ORBITOFRONTAL CORTEX; PREFRONTAL CORTEX; BRAIN; REDUCTION; EMOTION; MRI Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47093