Universität zu Köln

Scharwey, Melanie, Tatsuta, Takashi and Langer, Thomas ORCID: 0000-0003-1250-1462 (2013). Mitochondrial lipid transport at a glance. J. Cell Sci., 126 (23). S. 5317 - 5324. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9137

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Abstract

Lipids are the building blocks of cellular membranes and are synthesized at distinct parts of the cell. A precise control of lipid synthesis and distribution is crucial for cell function and survival. The endoplasmic reticulum (ER) is the major lipidsynthesizing organelle. However, a subset of lipids is synthesized within mitochondria, and this aspect has become a focus of recent lipid research. Mitochondria form a dynamic membrane network that is reshaped by fusion and fission events. Their functionality therefore depends on a continuous lipid supply from the ER and the distribution of lipids between both mitochondrial membranes. The mechanisms of mitochondrial lipid trafficking are only now emerging and appear to involve membrane contact sites and lipid transfer proteins. In this Cell Science at a Glance article, we will discuss recent discoveries in the field of mitochondrial lipid trafficking that build on long-standing observations and shed new light on the shuttling of membrane lipids between mitochondria and other organelles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scharwey, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-471492
DOI:	10.1242/jcs.134130
Journal or Publication Title:	J. Cell Sci.
Volume:	126
Number:	23
Page Range:	S. 5317 - 5324
Date:	2013
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9137
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE REGULATORY PROTEIN; ENDOPLASMIC-RETICULUM; RAT-LIVER; SACCHAROMYCES-CEREVISIAE; MEMBRANE-FRACTION; PHOSPHATIDYLSERINE TRANSPORT; INTRAMITOCHONDRIAL TRANSPORT; PHOSPHOLIPID SCRAMBLASE; SUBCELLULAR ORGANELLES; ENCOUNTER STRUCTURE Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47149