Universität zu Köln

Ramsey, Jordan M., Schwarz, Emanuel, Guest, Paul C., van Beveren, Nico J. M., Leweke, F. Markus ORCID: 0000-0002-8163-195X, Rothermundt, Matthias, Bogerts, Bernhard, Steiner, Johann ORCID: 0000-0002-2611-2268 and Bahn, Sabine (2013). Distinct Molecular Phenotypes in Male and Female Schizophrenia Patients. PLoS One, 8 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background: In schizophrenia, sex specific dimorphisms related to age of onset, course of illness and response to antipsychotic treatment may be mirrored by sex-related differences in the underlying molecular pathways. Methodology/Principal Findings: Here, we have carried out multiplex immunoassay profiling of sera from 4 independent cohorts of first episode antipsychotic naive schizophrenia patients (n = 133) and controls (n = 133) to identify such sex-specific illness processes in the periphery. The concentrations of 16 molecules associated with hormonal, inflammation and growth factor pathways showed significant sex differences in schizophrenia patients compared with controls. In female patients, the inflammation-related analytes alpha-1-antitrypsin, B lymphocyte chemoattractant BLC and interleukin-15 showed negative associations with positive and negative syndrome scale (PANSS) scores. In male patients, the hormones prolactin and testosterone were negatively associated with PANSS ratings. In addition, we investigated molecular changes in a subset of 33 patients before and after 6 weeks of treatment with antipsychotics and found that treatment induced sex-specific changes in the levels of testosterone, serum glutamic oxaloacetic transaminase, follicle stimulating hormone, interleukin-13 and macrophage-derived chemokine. Finally, we evaluated overlapping and distinct biomarkers in the sex-specific molecular signatures in schizophrenia, major depressive disorder and bipolar disorder. Conclusions/Significance: We propose that future studies should investigate the common and sex-specific aetiologies of schizophrenia, as the current findings suggest that different therapeutic strategies may be required for male and female patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ramsey, Jordan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Emanuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Guest, Paul C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Beveren, Nico J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leweke, F. Markus UNSPECIFIED orcid.org/0000-0002-8163-195X UNSPECIFIED Rothermundt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Bogerts, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiner, Johann UNSPECIFIED orcid.org/0000-0002-2611-2268 UNSPECIFIED Bahn, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-472052
DOI:	10.1371/journal.pone.0078729
Journal or Publication Title:	PLoS One
Volume:	8
Number:	11
Date:	2013
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOMARKERS; ASSOCIATIONS; 1ST-EPISODE; AUTOIMMUNE; ELEVATION; GENDER; SERUM; ONSET; RISK Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47205