Universität zu Köln

Re, Alessandro ORCID: 0000-0003-1156-6395, Cattaneo, Chiara, Skert, Cristina, Balsalobre, Pascual, Michieli, Mariagrazia ORCID: 0000-0001-6302-0488, Bower, Mark ORCID: 0000-0002-4077-6351, Ferreri, Andres J. M., Hentrich, Marcus, Ribera, Jose M., Allione, Bernardino, Schommers, Philipp ORCID: 0000-0003-3375-6800, Montoto, Silvia ORCID: 0000-0002-3006-9725, Almici, Camillo ORCID: 0000-0002-9438-2569, Ferremi, Pierino, Mazzucato, Mario ORCID: 0000-0001-8319-053X, Gattillo, Salvatore, Casari, Salvatore, Spina, Michele ORCID: 0000-0001-6576-8182, Diez-Martin, Jose L., Tirelli, Umberto and Rossi, Giuseppe ORCID: 0000-0001-8377-2898 (2013). Stem cell mobilization in HIV seropositive patients with lymphoma. Haematologica, 98 (11). S. 1762 - 1769. PAVIA: FERRATA STORTI FOUNDATION. ISSN 0390-6078

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Abstract

High-dose chemotherapy with autologous peripheral blood stem cell rescue has been reported as feasible and effective in HIV-associated lymphoma. Although a sufficient number of stem cells seems achievable in most patients, there are cases of stem cell harvest failure. The aim of this study was to describe the mobilization policies used in HIV-associated lymphoma, evaluate the failure rate and identify factors influencing mobilization results. We analyzed 155 patients who underwent attempted stem cell mobilization at 10 European centers from 2000-2012. One hundred and twenty patients had non-Hodgkin lymphoma and 35 Hodgkin lymphoma; 31% had complete remission, 57% chemosensitive disease, 10% refractory disease, 2% untested relapse. Patients were mobilized with chemotherapy + G-CSF (86%) or G-CSF alone (14%); 73% of patients collected >2 and 48% >5 x 10(6) CD34(+) cells/kg. Low CD4+ count and refractory disease were associated with mobilization failure. Low CD4(+) count, low platelet count and mobilization with G-CSF correlated with lower probability to achieve >5 x 10(6) CD34(+) cells/kg, whereas cyclophosphamide >= 3 g/m(2) + G-CSF predicted higher collections. Circulating CD34(+) cells and CD34/WBC ratio were strongly associated with collection result. HIV infection alone should not preclude an attempt to obtain stem cells in candidates for autologous transplant as the results are comparable to the HIV-negative population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Re, Alessandro UNSPECIFIED orcid.org/0000-0003-1156-6395 UNSPECIFIED Cattaneo, Chiara UNSPECIFIED UNSPECIFIED UNSPECIFIED Skert, Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Balsalobre, Pascual UNSPECIFIED UNSPECIFIED UNSPECIFIED Michieli, Mariagrazia UNSPECIFIED orcid.org/0000-0001-6302-0488 UNSPECIFIED Bower, Mark UNSPECIFIED orcid.org/0000-0002-4077-6351 UNSPECIFIED Ferreri, Andres J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribera, Jose M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allione, Bernardino UNSPECIFIED UNSPECIFIED UNSPECIFIED Schommers, Philipp UNSPECIFIED orcid.org/0000-0003-3375-6800 UNSPECIFIED Montoto, Silvia UNSPECIFIED orcid.org/0000-0002-3006-9725 UNSPECIFIED Almici, Camillo UNSPECIFIED orcid.org/0000-0002-9438-2569 UNSPECIFIED Ferremi, Pierino UNSPECIFIED UNSPECIFIED UNSPECIFIED Mazzucato, Mario UNSPECIFIED orcid.org/0000-0001-8319-053X UNSPECIFIED Gattillo, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Casari, Salvatore UNSPECIFIED UNSPECIFIED UNSPECIFIED Spina, Michele UNSPECIFIED orcid.org/0000-0001-6576-8182 UNSPECIFIED Diez-Martin, Jose L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tirelli, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Rossi, Giuseppe UNSPECIFIED orcid.org/0000-0001-8377-2898 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-472351
DOI:	10.3324/haematol.2013.089052
Journal or Publication Title:	Haematologica
Volume:	98
Number:	11
Page Range:	S. 1762 - 1769
Date:	2013
Publisher:	FERRATA STORTI FOUNDATION
Place of Publication:	PAVIA
ISSN:	0390-6078
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HUMAN-IMMUNODEFICIENCY-VIRUS; NON-HODGKIN-LYMPHOMA; HIGH-DOSE THERAPY; ACTIVE ANTIRETROVIRAL THERAPY; PERIPHERAL-BLOOD; AUTOLOGOUS TRANSPLANTATION; INTENSIVE CHEMOTHERAPY; SALVAGE TREATMENT; RANDOMIZED-TRIAL; PROGENITOR CELLS Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47235