Universität zu Köln

Vent, Julia, Haidle, Bastian, Wedemeyer, Inga, Huebbers, Christian ORCID: 0000-0002-2934-1218, Siefer, Oliver, Semrau, Robert, Preuss, Simon F. and Klussmann, Jens (2013). p16 Expression in carcinoma of unknown primary: Diagnostic indicator and prognostic marker. Head Neck-J. Sci. Spec. Head Neck, 35 (11). S. 1521 - 1527. HOBOKEN: WILEY. ISSN 1097-0347

Full text not available from this repository.

Abstract

BackgroundCarcinoma of unknown primary (CUP) of the neck are heterogeneous tumors in their clinical and biological characteristics, and a preoperative prognostic marker is desirable to optimize staging and therapy and to improve outcome and survival. For CUP syndrome, no optimized diagnostic and treatment strategy or biomarker have yet been determined. MethodsForty-seven patients presenting with CUP syndrome were analyzed after thorough standard diagnostic staging procedures. All patients were surgically treated with tonsillectomy, neck dissection of the diseased neck, as well as adjuvant chemoradiation. The tissue of lymph node metastases (and, if found, of the primary tumor) was analyzed regarding expression of p16, epidermal growth factor receptor (EGFR), and presence of human papillomavirus (HPV) DNA. ResultsIn 39% of all cases (20 of 47), the primary cancer was found during diagnostic workup. If HPV DNA was detected in the neck lymph node metastasis, the primary cancer was significantly more frequently found in the oropharynx (p = .002). Patients with a p16-positive tumor had a significantly higher 5-year overall survival (OS; 33% vs 69%; p = .045, disease-free survival [DSF] 77% vs 89%; p = not significant [NS]). Patients with p16-positive neck metastasis and no detectable primary cancer had a better prognosis. Expression of EGFR in this series did not have a significant effect on prognosis. ConclusionIn patients presenting with CUP syndrome, p16 immunohistochemistry can serve to locate the primary cancer in the oropharynx. It is a positive prognostic indicator in patients with those heterogeneous cancers. Head Neck, 35: 1521-1526, 2013

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vent, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Haidle, Bastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wedemeyer, Inga UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebbers, Christian UNSPECIFIED orcid.org/0000-0002-2934-1218 UNSPECIFIED Siefer, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Semrau, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Preuss, Simon F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-472904
DOI:	10.1002/hed.23190
Journal or Publication Title:	Head Neck-J. Sci. Spec. Head Neck
Volume:	35
Number:	11
Page Range:	S. 1521 - 1527
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0347
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASES; IN-SITU HYBRIDIZATION; HUMAN-PAPILLOMAVIRUS; TONSILLAR CARCINOMAS; PRIMARY TUMOR; HEAD; NECK; CANCER; DNA Multiple languages Otorhinolaryngology; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47290