Universität zu Köln

Linkermann, A., Hackl, M. J., Kunzendorf, U., Walczak, H., Krautwald, S. and Jevnikar, A. M. (2013). Necroptosis in Immunity and Ischemia-Reperfusion Injury. Am. J. Transplant., 13 (11). S. 2797 - 2805. HOBOKEN: WILEY. ISSN 1600-6143

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Abstract

Transplantation is invariably associated with ischemia-reperfusion injury (IRI), inflammation and rejection. Resultant cell death has morphological features of necrosis but programmed cell death has been synonymous with apoptosis until pathways of regulated necrosis (RN) have been described. The best-studied RN pathway, necroptosis, is triggered by perturbation of caspase-8-mediated apoptosis and depends on receptor-interacting protein kinases 1 and 3 (RIPK1/RIPK3) as well as mixed linage kinase domain like to form the necroptosome. The release of cytosolic content and cell death-associated molecular patterns (CDAMPs) can trigger innate and promote adaptive immune responses. Thus, the form of cell death can substantially influence alloimmunity and graft survival. Necroptosis is a key element of IRI, and RIPK1 interference by RN-specific inhibitors such as necrostatin-1 protects from IRI in kidney, heart and brain. Necroptosis may be a general mechanism in response to other forms of inflammatory organ injury, and will likely emerge as a promising target in solid organ transplantation. As second-generation RIPK1 and RIPK3 inhibitors become available, clinical trials for the prevention of delayed graft function and attenuation of allograft rejection-mediated injury will emerge. These efforts will accelerate upon further identification of critical necroptosis-triggering receptor(s). Necroptosis, a recently identified form of necrosis regulated by receptor-interacting protein kinase 1/3, is rapidly emerging as a promising therapeutic target in ischemia, inflammatory organ injury and transplantation. Please see online supporting information for an accompanying video. Also see editorial by Mannon on page 2785 and article by Lau et al on page 2805.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Linkermann, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hackl, M. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kunzendorf, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Walczak, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krautwald, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jevnikar, A. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-473245
DOI:	10.1111/ajt.12448
Journal or Publication Title:	Am. J. Transplant.
Volume:	13
Number:	11
Page Range:	S. 2797 - 2805
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-6143
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-NECROSIS-FACTOR; CHAIN ASSEMBLY COMPLEX; MIXED LINEAGE KINASE; TNF-INDUCED NECROSIS; NECROTIC CELL-DEATH; PROGRAMMED NECROSIS; IN-VIVO; INDUCED SHOCK; LIVER-INJURY; DOMAIN-LIKE Multiple languages Surgery; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47324