Universität zu Köln

Patel, S. G., Amit, M., Yen, T. C., Liao, C. T., Chaturvedi, P., Agarwal, J. P., Kowalski, L. P., Ebrahimi, A., Clark, J. R., Cernea, C. R., Brandao, S. J., Kreppel, M., Zoeller, J., Fliss, D., Fridman, E., Bachar, G., Shpitzer, T., Bolzoni, V. A., Patel, P. R., Jonnalagadda, S., Robbins, K. T., Shah, J. P. and Gil, Z. (2013). Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research. Br. J. Cancer, 109 (8). S. 2087 - 2096. LONDON: NATURE PUBLISHING GROUP. ISSN 1532-1827

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Abstract

Background: Lymph node density (LND) has previously been reported to reliably predict recurrence risk and survival in oral cavity squamous cell carcinoma (OSCC). This multicenter international study was designed to validate the concept of LND in OSCC. Methods: The study included 4254 patients diagnosed as having OSCC. The median follow-up was 41 months. Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional control and distant metastasis rates were calculated using the Kaplan-Meier method. Lymph node density (number of positive lymph nodes/total number of excised lymph nodes) was subjected to multivariate analysis. Results: The OS was 49% for patients with LND <= 0.07 compared with 35% for patients with LND>0.07 (P<0.001). Similarly, the DSS was 60% for patients with LND <= 0.07 compared with 41% for those with LND>0.07 (P<0.001). Lymph node density reliably stratified patients according to their risk of failure within the individual N subgroups (P = 0.03). A modified TNM staging system based on LND ratio was consistently superior to the traditional system in estimating survival measures. Conclusion: This multi-institutional study validates the reliability and applicability of LND as a predictor of outcomes in OSCC. Lymph node density can potentially assist in identifying patients with poor outcomes and therefore for whom more aggressive adjuvant treatment is needed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Patel, S. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Amit, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yen, T. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liao, C. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chaturvedi, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Agarwal, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kowalski, L. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Clark, J. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cernea, C. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandao, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliss, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fridman, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachar, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shpitzer, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bolzoni, V. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Patel, P. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonnalagadda, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Robbins, K. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gil, Z. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-473992
DOI:	10.1038/bjc.2013.570
Journal or Publication Title:	Br. J. Cancer
Volume:	109
Number:	8
Page Range:	S. 2087 - 2096
Date:	2013
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1532-1827
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; UPPER AERODIGESTIVE TRACT; LOCALLY ADVANCED HEAD; NECK DISSECTION; PROGNOSTIC-FACTORS; RADICAL CYSTECTOMY; CLINICAL-TRIALS; POSTOPERATIVE RADIOTHERAPY; GASTRIC-CANCER; SURVIVAL Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47399