Universität zu Köln

Schlimp, Christoph J., Voelckel, Wolfgang, Inaba, Kenji, Maegele, Marc and Schoechl, Herbert (2013). Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/- fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study. Scand. J. Trauma Resusc. Emerg. Med., 21. LONDON: BIOMED CENTRAL LTD. ISSN 1757-7241

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Abstract

Background: Low plasma fibrinogen concentration is a predictor of poor outcome in major trauma patients. The role of fibrinogen concentrate for rapidly increasing fibrinogen plasma levels in severe trauma is not well defined. Methods: In this retrospective study we included severe trauma patients treated with fibrinogen concentrate alone (FC group), fibrinogen concentrate with prothrombin complex concentrate (FC-PCC group) or fibrinogen concentrate with PCC and fresh frozen plasma (FC-PCC-FFP group). PCC was generally administered as the second step of intraoperative therapy, while FFP was only administered as a third step. All patients received >= 1 g fibrinogen concentrate within 24 hours. Plasma fibrinogen concentration and ROTEM parameters upon emergency room (ER) admission, intensive care unit (ICU) admission, and after 24 hours were analysed. Results: Among 157 patients fulfilling the inclusion criteria, 83% were male; mean age was 44 years and median injury severity score (ISS) was 29. Standard coagulation tests reflected increasing severity of coagulopathy with increasing complexity of haemostatic therapy (highest severity in the FC-PCC-FFP group; p < 0.0001). Total 24-hour fibrinogen concentrate dose also increased with complexity of haemostatic therapy. Plasma fibrinogen concentration was maintained, with no significant difference between ER admission and ICU admission in all patient groups. FIBTEM clot firmness at 10 minutes (CA(10)) was similarly maintained, albeit with a small increase in the FC-PCC group. Fibrinogen concentration and FIBTEM CA(10) were within the normal range in all groups at 24 hours. The ratio of fibrinogen concentrate to red blood cells (g:U) ranged between 0.7:1.0 and 1.0:1.0. Conclusion: Fibrinogen concentrate therapy maintained fibrinogen concentration and FIBTEM CA(10) during the initial phase of trauma care until ICU admission. After 24 hours, these parameters were comparable between the three groups and within the normal range for each of them. Further studies are warranted to investigate the effect of fibrinogen concentrate on clinical outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schlimp, Christoph J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Voelckel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Inaba, Kenji UNSPECIFIED UNSPECIFIED UNSPECIFIED Maegele, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoechl, Herbert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-474151
DOI:	10.1186/1757-7241-21-74
Journal or Publication Title:	Scand. J. Trauma Resusc. Emerg. Med.
Volume:	21
Date:	2013
Publisher:	BIOMED CENTRAL LTD
Place of Publication:	LONDON
ISSN:	1757-7241
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language IN-VITRO MODEL; MASSIVE TRANSFUSION; TRANEXAMIC ACID; HEMOSTATIC FACTORS; CONTROLLED-TRIAL; BLUNT TRAUMA; COAGULOPATHY; THERAPY; REPLACEMENT; COAGULATION Multiple languages Emergency Medicine Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47415