Universität zu Köln

Driver, C. J., Watts, V., Bunck, A. C., Van Ham, L. M. and Volk, H. A. (2013). Assessment of cerebellar pulsation in dogs with and without Chiari-like malformation and syringomyelia using cardiac-gated cine magnetic resonance imaging. Vet. J., 198 (1). S. 88 - 92. OXFORD: ELSEVIER SCI LTD. ISSN 1532-2971

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Abstract

Canine Chiari-like malformation (CM) is characterised by herniation of part of the cerebellum through the foramen magnum. In humans with Chiari type I malformation (CM-I), abnormal pulsation of the cerebellum during the cardiac cycle has been documented and is pivotal to theories for the pathogenesis of syringomyelia (SM). In this retrospective study, cardiac-gated cine balanced fast field echo (bFEE) magnetic resonance imaging (MRI) was used to assess pulsation of the brain in dogs and to objectively measure the degree of cerebellar pulsation with the neck in a flexed position. Overall, 17 Cavalier King Charles Spaniels (CKCS) with CM, including eight with SM and nine without SM, were compared with six small breed control dogs. Linear regions of interest were generated for the length of cerebellar herniation from each phase of the cardiac cycle and the degree of cerebellar pulsation was subsequently calculated. Age, bodyweight and angle of neck flexion were also compared. CKCS with CM and SM had significantly greater pulsation of the cerebellum than control dogs (P = 0.003) and CKCS with CM only (P = 0.031). There was no significant difference in age, bodyweight and angle of neck flexion between the three groups. Cardiac-gated cine bFEE MRI permitted the dynamic visualisation of cerebellar pulsation in dogs. These findings support the current theories regarding the pathogenesis of SM secondary to CM and further highlight the similarities between canine CM and human CM-I. (C) 2013 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Driver, C. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Watts, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, A. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Ham, L. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Volk, H. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-474430
DOI:	10.1016/j.tvjl.2013.05.017
Journal or Publication Title:	Vet. J.
Volume:	198
Number:	1
Page Range:	S. 88 - 92
Date:	2013
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1532-2971
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language KING-CHARLES SPANIELS; CAUDAL CRANIAL FOSSA; I MALFORMATION; CAVALIER; FLOW Multiple languages Veterinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47443