Universität zu Köln

Roustit, Matthieu ORCID: 0000-0003-4475-1626, Blaise, Sophie ORCID: 0000-0001-7238-112X, Allanore, Yannick, Carpentier, Patrick H., Caglayan, Evren and Cracowski, Jean-Luc (2013). Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud's phenomenon: systematic review and meta-analysis of randomised trials. Ann. Rheum. Dis., 72 (10). S. 1696 - 1700. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2060

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Abstract

Introduction Recent controlled trials have assessed the efficacy of phospodiesterase-5 (PDE-5) inhibitors in secondary Raynaud's phenomenon (RP). However, the conclusions are conflicting, and whether these drugs are effective remains unclear. The objective of this meta-analysis was to determine the efficacy of PDE-5 inhibitors on Raynaud's Condition Score (RCS) and frequency and duration of attacks. Methods A systematic review of articles was performed (sources included Medline, Embase, Web of Science, the Cochrane Central Register of Controlled Trials). Only double-blind, randomised controlled trials (RCTs) were included. Studies were selected independently by two authors using predefined data fields, including study quality indicators. Results Six RCTs were included (one with sildenafil, one with modified-release sildenafil, three with tadalafil and one with vardenafil). PDE-5 inhibitors significantly decreased mean RCS by -0.46 (-0.74 to -0.17) (p=0.002), the daily frequency of ischaemic attacks by -0.49 (-0.71 to -0.28) (p<0.0001), and daily duration of RP attacks by -14.62 (-20.25 to -9.00) min (p<0.0001). Conclusions PDE-5 inhibitors appear to have significant but moderate efficacy in secondary RP. A further large RCT is needed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roustit, Matthieu UNSPECIFIED orcid.org/0000-0003-4475-1626 UNSPECIFIED Blaise, Sophie UNSPECIFIED orcid.org/0000-0001-7238-112X UNSPECIFIED Allanore, Yannick UNSPECIFIED UNSPECIFIED UNSPECIFIED Carpentier, Patrick H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caglayan, Evren UNSPECIFIED UNSPECIFIED UNSPECIFIED Cracowski, Jean-Luc UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475143
DOI:	10.1136/annrheumdis-2012-202836
Journal or Publication Title:	Ann. Rheum. Dis.
Volume:	72
Number:	10
Page Range:	S. 1696 - 1700
Date:	2013
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1468-2060
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PHENOMENON RESISTANT; DOUBLE-BLIND; SILDENAFIL Multiple languages Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47514