Universität zu Köln

Kuhn, Elmar W., Liakopoulos, Oliver J., Stange, Sebastian, Deppe, Antje-Christin, Slottosch, Ingo, Scherner, Maximilian, Choi, Yeong-Hoon and Wahlers, Thorsten (2013). Meta-Analysis of Patients Taking Statins Before Revascularization and Aortic Valve Surgery. Ann. Thorac. Surg., 96 (4). S. 1508 - 1517. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-6259

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Abstract

Statin intake before cardiac surgery is associated with favorable outcomes. We sought to analyze the evidence for statin pretreatment before isolated coronary artery bypass graft surgery and aortic valve replacement surgery. In this meta-analysis, we demonstrate beneficial results for the endpoints mortality, stroke, atrial fibrillation, and length of stay in hospital in 36,053 statin-pretreated coronary artery bypass graft surgery patients compared with control subjects retrieved from 32 studies, but fail to detect relevant advantages through preoperative statin therapy for 3,091 patients undergoing aortic valve replacement from four trials. Strict adherence to guidelines recommending statin treatment before CABG surgery is therefore mandatory. (C) 2013 by The Society of Thoracic Surgeons

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhn, Elmar W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liakopoulos, Oliver J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stange, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Deppe, Antje-Christin UNSPECIFIED UNSPECIFIED UNSPECIFIED Slottosch, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherner, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Yeong-Hoon UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475253
DOI:	10.1016/j.athoracsur.2013.04.096
Journal or Publication Title:	Ann. Thorac. Surg.
Volume:	96
Number:	4
Page Range:	S. 1508 - 1517
Date:	2013
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1552-6259
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORONARY-ARTERY-BYPASS; POSTOPERATIVE ATRIAL-FIBRILLATION; RANDOMIZED CONTROLLED-TRIALS; PREOPERATIVE STATIN; CARDIAC-SURGERY; CLINICAL-TRIALS; CARDIOPULMONARY BYPASS; HEART-SURGERY; GRAFT-SURGERY; THERAPY Multiple languages Cardiac & Cardiovascular Systems; Respiratory System; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47525