Universität zu Köln

Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Knight, David C., Manoliu, Andrei ORCID: 0000-0003-1230-5752, Schwerthoeffer, Dirk, Scherr, Martin, Meng, Chun, Shao, Junming, Peters, Henning, Doll, Anselm, Khazaie, Habibolah ORCID: 0000-0002-8066-9753, Drzezga, Alexander, Baeuml, Josef, Zimmer, Claus, Forstl, Hans ORCID: 0000-0002-6188-6883, Wohlschlaeger, Afra M., Riedl, Valentin ORCID: 0000-0002-2861-8449 and Sorg, Christian (2013). Aberrant intrinsic connectivity of hippocampus and amygdala overlap in the fronto-insular and dorsomedial-prefrontal cortex in major depressive disorder. Front. Hum. Neurosci., 7. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5161

Full text not available from this repository.

Abstract

Neuroimaging studies of major depressive disorder (MDD) have consistently observed functional and structural changes of the hippocampus (HP) and amygdale (AY). Thus, these brain regions appear to be critical elements of the pathophysiology of MDD. The HP and AY directly interact and show broad and overlapping intrinsic functional connectivity (iFC) to other brain regions. Therefore, we hypothesized the HP and AY would show a corresponding pattern of aberrant intrinsic connectivity in MDD. Resting-state functional MRI was acquired from 21 patients with MDD and 20 healthy controls. beta-Maps of region-of-interest-based FC for bilateral body of the HP and basolateral AY were used as surrogates for iFC of the HP and AY. Analysis of variance was used to compare beta-maps between MDD and healthy control groups, and included covariates for age and gender as well as gray matter volume of the HP and AY. The HP and AY of MDD patients showed an overlapping pattern of reduced FC to the dorsomedial-prefrontal cortex and fronto-insular operculum. Both of these regions are known to regulate the interactions among intrinsic networks (i.e., default mode, central executive, and salience networks) that are disrupted in MDD. These results provide the first evidence of overlapping aberrant HP and AY intrinsic connectivity in MDD. Our findings suggest that aberrant HP and AY connectivity may interact with dysfunctional intrinsic network activity in MDD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0003-3999-3807 UNSPECIFIED Knight, David C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Manoliu, Andrei UNSPECIFIED orcid.org/0000-0003-1230-5752 UNSPECIFIED Schwerthoeffer, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherr, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Meng, Chun UNSPECIFIED UNSPECIFIED UNSPECIFIED Shao, Junming UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Doll, Anselm UNSPECIFIED UNSPECIFIED UNSPECIFIED Khazaie, Habibolah UNSPECIFIED orcid.org/0000-0002-8066-9753 UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Baeuml, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Forstl, Hans UNSPECIFIED orcid.org/0000-0002-6188-6883 UNSPECIFIED Wohlschlaeger, Afra M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Valentin UNSPECIFIED orcid.org/0000-0002-2861-8449 UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475348
DOI:	10.3389/fnhum.2013.00639
Journal or Publication Title:	Front. Hum. Neurosci.
Volume:	7
Date:	2013
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATE FUNCTIONAL CONNECTIVITY; DEFAULT MODE NETWORK; GLOBAL SIGNAL; EMOTION REGULATION; BRAIN NETWORKS; LIFE EVENTS; SCALE; ANTICORRELATIONS; METAANALYSIS; EPISODE Multiple languages Neurosciences; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47534