Universität zu Köln

Yakushev, Igor, Chetelat, Gael, Fischer, Florian U., Landeau, Brigitte, Bastin, Christine ORCID: 0000-0002-4556-9490, Scheurich, Armin, Perrotin, Audrey, Bahri, Mohamed Ali, Drzezga, Alexander, Eustache, Francis ORCID: 0000-0003-4460-8686, Schreckenberger, Mathias, Fellgiebel, Andreas and Salmon, Eric ORCID: 0000-0003-2520-9241 (2013). Metabolic and structural connectivity within the default mode network relates to working memory performance in young healthy adults. Neuroimage, 79. S. 184 - 191. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Studies of functional connectivity suggest that the default mode network (DMN) might be relevant for cognitive functions. Here, we examined metabolic and structural connectivity between major DMN nodes, the posterior cingulate (PCC) and medial prefrontal cortex (MPFC), in relation to normal working memory (WM). DMN was captured using independent component analysis of [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) data from 35 young healthy adults (27.1 +/- 5.1 years). Metabolic connectivity, a correlation between FDG uptake in PCC and MPFC, was examined in groups of subjects with (relative to median) low (n = 18) and high (n = 17) performance on digit span backward test as an index of verbal WM. In addition, fiber tractography based on PCC and MPFC nodes as way points was performed in a subset of subjects. FDG uptake in the DMN nodes did not differ between high and low performers. However, significantly (p = 0.01) lower metabolic connectivity was found in the group of low performers. Furthermore, as compared to high performers, low performers showed lower density of the left superior cingulate bundle. Verbal WM performance is related to metabolic and structural connectivity within the DMN in young healthy adults. Metabolic connectivity as quantified with FDG-PET might be a sensitive marker of the normal variability in some cognitive functions. (c) 2013 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yakushev, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED Chetelat, Gael UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Florian U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Landeau, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Bastin, Christine UNSPECIFIED orcid.org/0000-0002-4556-9490 UNSPECIFIED Scheurich, Armin UNSPECIFIED UNSPECIFIED UNSPECIFIED Perrotin, Audrey UNSPECIFIED UNSPECIFIED UNSPECIFIED Bahri, Mohamed Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Eustache, Francis UNSPECIFIED orcid.org/0000-0003-4460-8686 UNSPECIFIED Schreckenberger, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Fellgiebel, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Salmon, Eric UNSPECIFIED orcid.org/0000-0003-2520-9241 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475445
DOI:	10.1016/j.neuroimage.2013.04.069
Journal or Publication Title:	Neuroimage
Volume:	79
Page Range:	S. 184 - 191
Date:	2013
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATE FUNCTIONAL CONNECTIVITY; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; FDG-PET; BRAIN CONNECTIVITY; GREY-MATTER; INTELLIGENCE; DEACTIVATION; REGIONS; HYPOMETABOLISM Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47544