Universität zu Köln

Rossig, C., Juergens, H., Schrappe, M., Moericke, A., Henze, G., von Stackelberg, A., Reinhardt, D., Burkhardt, B., Woessmann, W., Zimmermann, M., Gadner, H., Mann, G., Schellong, G., Mauz-Koerholz, C., Dirksen, U., Bielack, S., Berthold, F., Graf, N., Rutkowski, S., Calaminus, G., Kaatsch, P. and Creutzig, U. (2013). Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria. Pediatr. Blood Cancer, 60 (10). S. 1574 - 1582. HOBOKEN: WILEY. ISSN 1545-5017

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Abstract

In Germany and Austria, more than 90% of pediatric cancer patients are enrolled into nationwide disease-specific first-line clinical trials or interim registries. Essential components are a pediatric cancer registry and centralized reference laboratories, imaging review, and tumor board assistance. The five-year overall survival rate in countries where such infrastructures are established has improved from <20% before 1950 to >80% since 1995. Today, treatment intensity is tailored to the individual patient's risk to provide the highest chances of survival while minimizing deleterious late effects. Multicenter clinical trials are internationalized and serve as platforms for further improvements by novel drugs and biologicals. Pediatr Blood Cancer 2013;60:1574-1581. (c) 2013 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rossig, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Juergens, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schrappe, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moericke, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Henze, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED von Stackelberg, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhardt, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burkhardt, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Woessmann, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmermann, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gadner, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mann, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schellong, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mauz-Koerholz, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dirksen, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bielack, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berthold, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Graf, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rutkowski, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Calaminus, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaatsch, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Creutzig, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475619
DOI:	10.1002/pbc.24598
Journal or Publication Title:	Pediatr. Blood Cancer
Volume:	60
Number:	10
Page Range:	S. 1574 - 1582
Date:	2013
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1545-5017
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE LYMPHOBLASTIC-LEUKEMIA; HIGH-RISK NEUROBLASTOMA; CENTRAL-NERVOUS-SYSTEM; OF-PEDIATRIC-ONCOLOGY; LARGE-CELL LYMPHOMA; ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOID-LEUKEMIA; NON-HODGKINS-LYMPHOMA; BFM STUDY-GROUP; TERM-FOLLOW-UP Multiple languages Oncology; Hematology; Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47561