Universität zu Köln

Tria, F., Pompei, S. and Loreto, V. (2013). Dynamically correlated mutations drive human Influenza A evolution. Sci Rep, 3. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Human Influenza A virus undergoes recurrent changes in the hemagglutinin (HA) surface protein, primarily involved in the human antibody recognition. Relevant antigenic changes, enabling the virus to evade host immune response, have been recognized to occur in parallel to multiple mutations at antigenic sites in HA. Yet, the role of correlated mutations (epistasis) in driving the molecular evolution of the virus still represents a challenging puzzle. Further, though circulation at a global geographic level is key for the survival of Influenza A, its role in shaping the viral phylodynamics remains largely unexplored. Here we show, through a sequence based epidemiological model, that epistatic effects between amino acids substitutions, coupled with a reservoir that mimics worldwide circulating viruses, are key determinants that drive human Influenza A evolution. Our approach explains all the up-to-date observations characterizing the evolution of H3N2 subtype, including phylogenetic properties, nucleotide fixation patterns, and composition of antigenic clusters.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tria, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pompei, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loreto, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-475817
DOI:	10.1038/srep02705
Journal or Publication Title:	Sci Rep
Volume:	3
Date:	2013
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNITED-STATES; SEASONAL INFLUENZA; VIRUS; HEMAGGLUTININ; TRANSMISSION; MORTALITY; PATHOGENS; ESCAPE; IMPACT; SITES Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47581