Al Ghazal, Philipp, Herberger, Katharina, Schaller, Joerg, Stroelin, Anke, Hoff, Norman-Philipp, Goerge, Tobias, Roth, Hannelore, Rabe, Eberhard, Karrer, Sigrid, Renner, Regina, Maschke, Jan, Horn, Thomas, Hepp, Julia, Eming, Sabine, Wollina, Uwe ORCID: 0000-0001-5933-2913, Zutt, Markus, Sick, Isabell, Splieth, Benno, Dill, Dorothea, Klode, Joachim and Dissemond, Joachim (2013). Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. Orphanet J. Rare Dis., 8. LONDON: BIOMED CENTRAL LTD. ISSN 1750-1172

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Abstract

Background: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG. Methods: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany. Results: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome. Conclusions: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Al Ghazal, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herberger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaller, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stroelin, AnkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoff, Norman-PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goerge, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, HanneloreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabe, EberhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karrer, SigridUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Renner, ReginaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maschke, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hepp, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eming, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wollina, UweUNSPECIFIEDorcid.org/0000-0001-5933-2913UNSPECIFIED
Zutt, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sick, IsabellUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Splieth, BennoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dill, DorotheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klode, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dissemond, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-476031
DOI: 10.1186/1750-1172-8-136
Journal or Publication Title: Orphanet J. Rare Dis.
Volume: 8
Date: 2013
Publisher: BIOMED CENTRAL LTD
Place of Publication: LONDON
ISSN: 1750-1172
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PAPA SYNDROME; CLINICOPATHOLOGICAL CORRELATION; AUTOINFLAMMATORY SYNDROME; INFLAMMATORY DISEASES; PYOGENIC ARTHRITIS; ACNE; SKIN; TRAFFICKING; MUTATIONMultiple languages
Genetics & Heredity; Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47603

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