Universität zu Köln

Neidhart, Johannes, Szendro, Ivan G. and Krug, Joachim ORCID: 0000-0002-2143-6490 (2013). Exact results for amplitude spectra of fitness landscapes. J. Theor. Biol., 332. S. 218 - 228. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1095-8541

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Abstract

Starting from fitness correlation functions, we calculate exact expressions for the amplitude spectra of fitness landscapes as defined by Stadler [1996. Landscapes and their correlation functions. J. Math. Chem. 20,1] for common landscape models, including Kauffman's NK-model, rough Mount Fuji landscapes and general linear superpositions of such landscapes. We further show that correlations decaying exponentially with the Hamming distance yield exponentially decaying spectra similar to those reported recently for a model of molecular signal transduction. Finally, we compare our results for the model systems to the spectra of various experimentally measured fitness landscapes. We claim that our analytical results should be helpful when trying to interpret empirical data and guide the search for improved fitness landscape models. (C) 2013 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neidhart, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Szendro, Ivan G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476042
DOI:	10.1016/j.jtbi.2013.05.002
Journal or Publication Title:	J. Theor. Biol.
Volume:	332
Page Range:	S. 218 - 228
Date:	2013
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1095-8541
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BENEFICIAL MUTATIONS; POPULATION-GENETICS; NK MODEL; ADAPTATION; EPISTASIS; EVOLUTION; SELECTION Multiple languages Biology; Mathematical & Computational Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47604