Universität zu Köln

Roehrig, G., Nobbe, C., Weiss, V. and Schulz, R. -J. (2013). Hepcidin in anaemic geriatric patients with non-dialysis chronic kidney disease (ND-CKD). Eur. Geriatr. Med., 4 (4). S. 221 - 226. NEW YORK: SPRINGER. ISSN 1878-7657

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Abstract

Purpose: Although data respecting prevalence of anemia in elderly non-dialysis chronic kidney disease (ND-CKD) patients are still rare, prevalence is supposed to be high, as CKD and anemia increase with age. Hepcidin is a key regulator of iron homeostasis and elevated serum levels reduce enteral iron resorption, making oral iron substitution ineffective. In this setting, a state of functional iron deficiency may develop in ND-CKD and lead to anaemia due to iron-restricted erythropoiesis. Dependence of hepcidin on glomerular filtration rate (GFR) in younger ND-CKD patients could be shown recently. The present study was intended to analyse the dependence of serum hepcidin levels on GFR in anaemic geriatric patients > 60 years suffering from ND-CKD. Methods: Explorative study; 53 patients were selected among in-patients of geriatric department; selection criteria were: non-dialysis CKD, presence of anemia (< 12 g/dL in women, <13 g/dL in men); transferrin saturation (TSAT) < 16%, C-reactive protein (CRP) < 5 mg/L. Serum hepcidin was analysed by a commercially available ELISA kit (DRG, Marburg, Germany). Findings were evaluated by statistical means. Results: Data reveal a positive correlation between hepcidin and ferritin (P < 0.001) as well as between TSAT and GFR (P = 0.027) and a negative correlation between hepcidin and GFR (P = 0.035). These findings are of statistical significance at a significance level of 0.05. All analyses are of an explorative nature. Conclusions: As seen in younger patients, we could show a similar dependence of hepcidin serum levels on GFR in elderly anaemic patients suffering from ND-CKD. This finding underlines the option for intravenous iron supplementation in ND-CKD of the elderly. Randomized studies are needed. (C) 2013 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roehrig, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nobbe, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, R. -J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476274
DOI:	10.1016/j.eurger.2013.04.010
Journal or Publication Title:	Eur. Geriatr. Med.
Volume:	4
Number:	4
Page Range:	S. 221 - 226
Date:	2013
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1878-7657
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STAGE RENAL-DISEASE; IRON-DEFICIENCY; UNITED-STATES; PREVALENCE; MORTALITY; FAILURE Multiple languages Geriatrics & Gerontology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47627