Universität zu Köln

Barbui, Tiziano, Finazzi, Guido, Carobbio, Alessandra ORCID: 0000-0001-9664-7084, Thiele, Juergen, Passamonti, Francesco ORCID: 0000-0001-8068-5289, Rumi, Elisa ORCID: 0000-0002-7572-9504, Ruggeri, Marco, Rodeghiero, Francesco, Randi, Maria Luigia, Bertozzi, Irene, Gisslinger, Heinz, Buxhofer-Ausch, Veronika, De Stefano, Valerio ORCID: 0000-0002-5178-5827, Betti, Silvia, Rambaldi, Alessandro ORCID: 0000-0002-3739-7502, Vannucchi, Alessandro M. and Tefferi, Ayalew (2012). Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood, 120 (26). S. 5128 - 5134. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

Accurate prediction of thrombosis in essential thrombocythemia (ET) provides the platform for prospective studies exploring preventive measures. Current risk stratification for thrombosis in ET is 2-tiered and considers low-and high-risk categories based on the respective absence or presence of either age > 60 years or history of thrombosis. In an international study of 891 patients with World Health Organization (WHO)-defined ET, we identified additional independent risk factors including cardiovascular risk factors and JAK2V617F. Accordingly, we assigned risk scores based on multivariable analysis-derived hazard ratios (HRs) to age > 60 years (HR = 1.5; 1 point), thrombosis history (HR = 1.9; 2 points), cardiovascular risk factors (HR = 1.6; 1 point), and JAK2V617F (HR = 2.0; 2 points) and subsequently devised a 3-tiered prognostic model (low-risk = < 2 points; intermediate-risk = 2 points; and high-risk = > 2 points) using a training set of 535 patients and validated the results in the remaining cohort (n = 356; internal validation set) and in an external validation set (n = 329). Considering all 3 cohorts (n = 1220), the 3-tiered new prognostic model (low-risk n = 474 vs intermediate-risk n = 471 vs high-risk n = 275), with a respective thrombosis risk of 1.03% of patients/y versus 2.35% of patients/y versus 3.56% of patients/y, outperformed the 2-tiered (low-risk 0.95% of patients/y vs high-risk 2.86% of patients/y) conventional risk stratification in predicting future vascular events. (Blood. 2012; 120(26): 5128-5133)

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barbui, Tiziano UNSPECIFIED UNSPECIFIED UNSPECIFIED Finazzi, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Carobbio, Alessandra UNSPECIFIED orcid.org/0000-0001-9664-7084 UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Passamonti, Francesco UNSPECIFIED orcid.org/0000-0001-8068-5289 UNSPECIFIED Rumi, Elisa UNSPECIFIED orcid.org/0000-0002-7572-9504 UNSPECIFIED Ruggeri, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Rodeghiero, Francesco UNSPECIFIED UNSPECIFIED UNSPECIFIED Randi, Maria Luigia UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertozzi, Irene UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisslinger, Heinz UNSPECIFIED UNSPECIFIED UNSPECIFIED Buxhofer-Ausch, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED De Stefano, Valerio UNSPECIFIED orcid.org/0000-0002-5178-5827 UNSPECIFIED Betti, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rambaldi, Alessandro UNSPECIFIED orcid.org/0000-0002-3739-7502 UNSPECIFIED Vannucchi, Alessandro M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tefferi, Ayalew UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476538
DOI:	10.1182/blood-2012-07-444067
Journal or Publication Title:	Blood
Volume:	120
Number:	26
Page Range:	S. 5128 - 5134
Date:	2012
Publisher:	AMER SOC HEMATOLOGY
Place of Publication:	WASHINGTON
ISSN:	1528-0020
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TYROSINE KINASE JAK2; POLYCYTHEMIA-VERA; RISK STRATIFICATION; V617F MUTATION; LEUKOCYTOSIS; SURVIVAL; MANAGEMENT; ARTERIAL Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47653