Universität zu Köln

Shen, Yidong, Wollam, Joshua, Magner, Daniel, Karalay, Oezlem and Antebi, Adam (2012). A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad. Science, 338 (6113). S. 1472 - 1478. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two-to-stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Shen, Yidong UNSPECIFIED UNSPECIFIED UNSPECIFIED Wollam, Joshua UNSPECIFIED UNSPECIFIED UNSPECIFIED Magner, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Karalay, Oezlem UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-476704
DOI:	10.1126/science.1228967
Journal or Publication Title:	Science
Volume:	338
Number:	6113
Page Range:	S. 1472 - 1478
Date:	2012
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELLS; LONGEVITY; DAF-16 Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47670