Universität zu Köln

Kolk, Andreas, Handschel, Joerg, Drescher, Wolf, Rothamel, Daniel, Kloss, Frank, Blessmann, Marco, Heiland, Max ORCID: 0000-0002-4987-2913, Wolff, Klaus-Dietrich and Smeets, Ralf (2012). Current trends and future perspectives of bone substitute materials - From space holders to innovative biomaterials. J. Cranio-MaxilloFac. Surg., 40 (8). S. 706 - 719. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging. (C) 2012 European Association for Cranio-Maxillo-Facial Surgery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kolk, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Handschel, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Drescher, Wolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothamel, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloss, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Blessmann, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiland, Max UNSPECIFIED orcid.org/0000-0002-4987-2913 UNSPECIFIED Wolff, Klaus-Dietrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Smeets, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-478020
DOI:	10.1016/j.jcms.2012.01.002
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	40
Number:	8
Page Range:	S. 706 - 719
Date:	2012
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EMBRYONIC STEM-CELLS; TRICALCIUM PHOSPHATE; MORPHOGENETIC PROTEIN-2; RIDGE PRESERVATION; ILIAC CREST; CALCIUM; MATRIX; GRAFT; HYDROXYAPATITE; AUGMENTATION Multiple languages Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47802