Universität zu Köln

Sprooten, Emma ORCID: 0000-0002-1691-9105, McIntosh, Andrew M., Lawrie, Stephen M., Hall, Jeremy ORCID: 0000-0002-0403-3278, Sussmann, Jess E., Dahmen, Norbert, Konrad, Andreas, Bastin, Mark E. and Winterer, Georg (2012). An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain. Magn. Reson. Imaging, 30 (10). S. 1373 - 1381. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-5894

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Abstract

ZNF804A, a genomewide supported susceptibility gene for schizophrenia and bipolar disorder, has been associated with task-independent functional connectivity between the left and right dorsolateral prefrontal cortices. Several lines of evidence have converged on the hypothesis that this effect may be mediated by structural connectivity. We tested this hypothesis using diffusion tensor magnetic resonance imaging in three samples: one German sample of 50 healthy individuals, one Scottish sample of 83 healthy individuals and one Scottish sample of 84 unaffected relatives of bipolar patients. Voxel-based analysis and tract-based spatial statistics did not detect any fractional anisotropy (FA) differences between minor allele carriers and individuals homozygous for the major allele at rs1344706. Similarly, region-of-interest analyses and quantitative tractography of the genu of the corpus callosum revealed no significant FA differences between the genotype groups. Examination of effect sizes and confidence intervals indicated that this negative finding is very unlikely to be due to a lack of statistical power. In summary, despite using various analysis techniques in three different samples, our results were strikingly and consistently negative. These data therefore suggest that it is unlikely that the effects of genetic variation at rs1344706 on functional connectivity are mediated by structural integrity differences in large, long-range white matter fiber connections. (C) 2012 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sprooten, Emma UNSPECIFIED orcid.org/0000-0002-1691-9105 UNSPECIFIED McIntosh, Andrew M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lawrie, Stephen M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hall, Jeremy UNSPECIFIED orcid.org/0000-0002-0403-3278 UNSPECIFIED Sussmann, Jess E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahmen, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Bastin, Mark E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Winterer, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-478089
DOI:	10.1016/j.mri.2012.05.013
Journal or Publication Title:	Magn. Reson. Imaging
Volume:	30
Number:	10
Page Range:	S. 1373 - 1381
Date:	2012
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1873-5894
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUSCEPTIBILITY GENE ZNF804A; RISK; SCHIZOPHRENIA; MICROSTRUCTURE; CONNECTIVITY; INDIVIDUALS; ASSOCIATION; SIZE; DTI Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47808