Universität zu Köln

Greimel, Ellen, Nehrkorn, Barbara, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Kukolja, Juraj ORCID: 0000-0003-1569-3287, Kohls, Gregor, Mueller, Kristin, Piefke, Martina, Kamp-Becker, Inge, Remschmidt, Helmut, Herpertz-Dahlmann, Beate, Konrad, Kerstin ORCID: 0000-0001-9039-2615 and Schulte-Ruether, Martin (2012). Neural mechanisms of encoding social and non-social context information in autism spectrum disorder. Neuropsychologia, 50 (14). S. 3440 - 3450. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-3514

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Abstract

Individuals with autism spectrum disorder (ASD) often fail to attach context to their memories and are specifically impaired in processing social aspects of contextual information. The aim of the present study was to investigate the modulatory influence of social vs. non-social context on neural mechanisms during encoding in ASD. Using event-related fMRI, 13 boys with ASD and 13 typically developing boys comparable for age and IQ were investigated during encoding of neutral objects presented either with a social (faces) or a non-social (houses) context. A memory paradigm was then applied to identify brain activation patterns associated with encoding of subsequently recollected versus non-recollected objects. On the behavioural level, no significant between-group differences emerged. In particular, no differential effects of context on memory performance were observed. Neurally, however, context-specific group differences were observed in several brain regions. During encoding of subsequently recollected objects presented with a face. ASD subjects (compared to controls) showed reduced neural activation in the bilateral inferior frontal gyrus, bilateral middle frontal gyrus and right inferior parietal lobule. Neural activation in the right inferior frontal gyrus was positively correlated with memory performance in controls, but negatively in ASD individuals. During encoding of subsequently non-recollected objects presented in the non-social context, ASD subjects showed increased activation in the dorsal MPFC. Our findings suggest that in ASD subjects, fronto-parietal brain regions subserving memory formation and the association of contextual information are activated atypically when a social context is presented at encoding. The data add to findings from related research fields indicating that in ASD, socioemotional impairment extends into domains beyond social cognition. Increased activation in the dorsal MPFC in ASD individuals might reflect supervisory cognitive processes related to the suppression of a distracting non-social context. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Greimel, Ellen UNSPECIFIED UNSPECIFIED UNSPECIFIED Nehrkorn, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Kukolja, Juraj UNSPECIFIED orcid.org/0000-0003-1569-3287 UNSPECIFIED Kohls, Gregor UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Kristin UNSPECIFIED UNSPECIFIED UNSPECIFIED Piefke, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamp-Becker, Inge UNSPECIFIED UNSPECIFIED UNSPECIFIED Remschmidt, Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Herpertz-Dahlmann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Konrad, Kerstin UNSPECIFIED orcid.org/0000-0001-9039-2615 UNSPECIFIED Schulte-Ruether, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-478155
DOI:	10.1016/j.neuropsychologia.2012.09.029
Journal or Publication Title:	Neuropsychologia
Volume:	50
Number:	14
Page Range:	S. 3440 - 3450
Date:	2012
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-3514
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE CONTROL; EPISODIC MEMORY; EMOTIONAL CONTEXT; CHILDREN; CORTEX; DEFICITS; ADULTS; FMRI; MODULATION; ACTIVATION Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47815