Universität zu Köln

Ueki, Hiroshi, Mizushina, Tomona, Laoharatchatathanin, Titaree, Terashima, Ryota ORCID: 0000-0002-9339-6651, Nishimura, Yasuhiro, Rieanrakwong, Duangjai, Yonezawa, Tomohiro, Kurusu, Shiro, Hasegawa, Yoshihisa, Brachvogel, Bent, Poeschl, Ernst and Kawaminami, Mitsumori (2012). Loss of Maternal Annexin A5 Increases the Likelihood of Placental Platelet Thrombosis and Foetal Loss. Sci Rep, 2. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null mice (Anxa5-KO). These changes occurred even when only the mother was Anxa5-KO. A small amount of placental fibrin deposition was observed in the decidual tissues, but did not noticeably differ between wild-type and Anxa5-KO mice. However, immunoreactivity for integrin beta 3/CD61, a platelet marker, was demonstrated within thrombi in the arterial canals only in Anxa5-KO mothers. Subcutaneous administration of the anticoagulant heparin to pregnant Anxa5-KO mice significantly reduced pregnancy loss, suggesting that maternal Anxa5 is crucial for maintaining intact placental circulation. Hence, the presence of maternal Anxa5 minimises the risk of thrombosis in the placental circulation and reduces the risk of foetal loss.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ueki, Hiroshi UNSPECIFIED UNSPECIFIED UNSPECIFIED Mizushina, Tomona UNSPECIFIED UNSPECIFIED UNSPECIFIED Laoharatchatathanin, Titaree UNSPECIFIED UNSPECIFIED UNSPECIFIED Terashima, Ryota UNSPECIFIED orcid.org/0000-0002-9339-6651 UNSPECIFIED Nishimura, Yasuhiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Rieanrakwong, Duangjai UNSPECIFIED UNSPECIFIED UNSPECIFIED Yonezawa, Tomohiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurusu, Shiro UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasegawa, Yoshihisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Brachvogel, Bent UNSPECIFIED UNSPECIFIED UNSPECIFIED Poeschl, Ernst UNSPECIFIED UNSPECIFIED UNSPECIFIED Kawaminami, Mitsumori UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479056
DOI:	10.1038/srep00827
Journal or Publication Title:	Sci Rep
Volume:	2
Date:	2012
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GONADOTROPIN-RELEASING-HORMONE; RIBONUCLEIC-ACID EXPRESSION; EARLY-PREGNANCY LOSS; ANTIPHOSPHOLIPID ANTIBODIES; ANTICOAGULANT PROTEIN; V ANTIBODIES; CELLS; APOPTOSIS; WOMEN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47905