Universität zu Köln

Galldiks, Norbert ORCID: 0000-0002-2485-1796, Dunkl, Veronika, Kracht, Lutz W., Vollmar, Stefan, Jacobs, Andreas H., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Schroeter, Michael (2012). Volumetry of [C-11]-Methionine Positron Emission Tomographic Uptake as a Prognostic Marker before Treatment of Patients with Malignant Glioma. Mol. Imaging, 11 (6). S. 516 - 528. HAMILTON: B C DECKER INC. ISSN 1535-3508

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Abstract

The purpose of this positron emission tomography (PET) study was to compare the prognostic value of pretreatment volume of [ 11 C]methionine (MET) uptake and semiquantitative MET uptake ratio in patients with malignant glioma. The study population comprised 40 patients with malignant glioma. Pretreatment magnetic resonance imaging (MRI) and MET-PET imaging were performed before the initiation of glioma treatment in all patients. The pretreatment MET uptake ratios and volumes were assessed. To create prognostically homogeneous subgroups, patients' pretreatment prognostic factors were stratified according to the six classes of Radiation Therapy Oncology Group recursive partitioning analysis (RTOG RPA). Univariate and multivariate analyses were performed to determine significant prognostic factors. Survival analyses identified the pretreatment volume of MET uptake and a higher RTOG RPA class as significant predictors. In contrast, pretreatment maximum areas of contrast enhancement on MRI and semiquantitative MET uptake ratios could not be identified as significant prognostic factors. The patients' outcomes and Karnofsky Performance Scale scores were significantly correlated with pretreatment volume of MET uptake but not with semiquantitative MET uptake ratio. The data suggest that pretreatment volumetry of MET uptake but not the semiquantitative MET uptake ratio is a useful biologic prognostic marker in patients with malignant glioma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Dunkl, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Kracht, Lutz W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vollmar, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobs, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479152
DOI:	10.2310/7290.2012.00022
Journal or Publication Title:	Mol. Imaging
Volume:	11
Number:	6
Page Range:	S. 516 - 528
Date:	2012
Publisher:	B C DECKER INC
Place of Publication:	HAMILTON
ISSN:	1535-3508
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-GRADE GLIOMAS; RECURSIVE PARTITIONING ANALYSIS; GLIOBLASTOMA-MULTIFORME; C-11-METHIONINE PET; TEMOZOLOMIDE CHEMOTHERAPY; ADJUVANT TEMOZOLOMIDE; TARGET DELINEATION; CEREBRAL GLIOMAS; TUMOR EXTENT; BRAIN-TUMORS Multiple languages Biochemical Research Methods; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47915