Chmielewski, Markus, Maliar, Amit, Eshhar, Zelig and Abken, Hinrich (2012). CAR's made it to the pancreas. OncoImmunology, 1 (8). S. 1387 - 1390. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 2162-402X

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Abstract

Despite intensive treatment, pancreatic adenocarcinoma still has the worst prognosis among all malignancies. Using clinically relevant models, we demonstrated the therapeutic efficacy of adoptively transferred T cells engineered with a carcinoembryonic antigen (CEA) and ERBB2-specific chimeric antigen receptor against pancreatic carcinoma. Targeting CD24, a putative cancer stem cell antigen expressed by a minority of carcinoma cells, was likewise effective.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Chmielewski, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maliar, AmitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eshhar, ZeligUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Abken, HinrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-479245
DOI: 10.4161/onci.22195
Journal or Publication Title: OncoImmunology
Volume: 1
Number: 8
Page Range: S. 1387 - 1390
Date: 2012
Publisher: TAYLOR & FRANCIS INC
Place of Publication: PHILADELPHIA
ISSN: 2162-402X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
T-CELLS; TUMORSMultiple languages
Oncology; ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47924

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