Universität zu Köln

Krug, K. B., Rehder, O., Bovenschulte, H., Schwabe, H., Burst, V., Engelmann, U., Thul, R., Moenig, S. and Hellmich, M. (2012). Effects of endovascular therapy for renal artery stenosis on blood pressure and renal function. Retrospective analysis of an unselected patient collective from 1994 to 2007. Urologe, 51 (11). S. 1562 - 1570. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0563

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Abstract

A retrospective analysis of the long-term success rates of endoluminal therapy of renal artery stenosis in a university hospital was carried out. Preinterventional and postinterventional data contained in the clinical records of all 104 patients who underwent percutaneous transluminal angioplasty (PTA, 25 patients) or stent PTA (79 patients) from 01 January 1994 to 31 December 2007, were documented using an electronically structured questionnaire and a time period classification. Subgroup analyses and statistical calculations were done using t-tests for joint random samples. At day 1 postintervention all patients showed a statistically significant decrease in mean systolic blood pressure (all patients: p=0.002, stent PTA group: p=0.023, PTA group: p=0.022). The significant decrease in mean systolic blood pressure persisted in years 1 and 2 postintervention (all patients: p=0.009 and 0.007, stent PTA group: p=0.039 and 0.015, respectively). Mean blood pressure values remained constant during the other time periods analyzed. In patients with a stent PTA carried out between 2001 and 2007 there was no significant reduction of prescribed antihypertonic drugs (p=0.023 and p=0.046, respectively). Mean serum creatinine concentrations decreased during years 1 and 2 postintervention and increased starting in year 3. In patients with elevated serum creatinine levels prior to the intervention the increase in mean serum creatinine level started in year 5. Endoluminal therapy of arteriosclerotic renal artery stenosis delays further deterioration of renal function and stabilizes blood pressure as well as the number of prescribed antihypertonic drugs. This can be considered a response to treatment in view of the mostly chronic progressive course of the disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krug, K. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehder, O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bovenschulte, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwabe, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Burst, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelmann, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thul, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Moenig, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479321
DOI:	10.1007/s00120-012-2952-0
Journal or Publication Title:	Urologe
Volume:	51
Number:	11
Page Range:	S. 1562 - 1570
Date:	2012
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0563
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 4-YEAR FOLLOW-UP; RENOVASCULAR HYPERTENSION; BALLOON ANGIOPLASTY; MEDICAL THERAPY; REVASCULARIZATION; STENT Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47932