Universität zu Köln

Bluemel, Marcus, Guschlbauer, Christoph, Daun-Gruhn, Silvia, Hooper, Scott L. and Bueschges, Ansgar (2012). Hill-type muscle model parameters determined from experiments on single muscles show large animal-to-animal variation. Biol. Cybern., 106 (10). S. 559 - 572. NEW YORK: SPRINGER. ISSN 0340-1200

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Abstract

Models built using mean data can represent only a very small percentage, or none, of the population being modeled, and produce different activity than any member of it. Overcoming this averaging pitfall requires measuring, in single individuals in single experiments, all of the system's defining characteristics. We have developed protocols that allow all the parameters in the curves used in typical Hill-type models (passive and active force-length, series elasticity, force-activation, force-velocity) to be determined from experiments on individual stick insect muscles (Blumel et al. 2012a). A requirement for means to not well represent the population is that the population shows large variation in its defining characteristics. We therefore used these protocols to measure extensor muscle defining parameters in multiple animals. Across-animal variability in these parameters can be very large, ranging from 1.3- to 17-fold. This large variation is consistent with earlier data in which extensor muscle responses to identical motor neuron driving showed large animal-to-animal variability (Hooper et al. 2006), and suggests accurate modeling of extensor muscles requires modeling individual-by-individual. These complete characterizations of individual muscles also allowed us to test for parameter correlations. Two parameter pairs significantly co-varied, suggesting that a simpler model could as well reproduce muscle response.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bluemel, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Guschlbauer, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Daun-Gruhn, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hooper, Scott L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bueschges, Ansgar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-479700
DOI:	10.1007/s00422-012-0530-6
Journal or Publication Title:	Biol. Cybern.
Volume:	106
Number:	10
Page Range:	S. 559 - 572
Date:	2012
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	0340-1200
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language APLYSIA FEEDING-BEHAVIOR; NEUROMUSCULAR ACTIVITY; CYCLE VARIABILITY; STICK INSECT Multiple languages Computer Science, Cybernetics; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/47970