Roll, Petra, Ostermeier, Eva, Haubitz, Marion, Lovric, Svjetlana, Unger, Leonore, Holle, Julia, Koetter, Ina ORCID: 0000-0002-9262-005X, Henes, Joerg C., Bergner, Raoul ORCID: 0000-0002-7965-1273, Rubbert-Roth, Andrea, Specker, Christof ORCID: 0000-0003-2504-3229, Schulze-Koops, Hendrik, Mueller-Ladner, Ulf, Fleck, Martin, Burmester, Gerd-Ruediger, Hiepe, Falk ORCID: 0000-0003-3584-5292, Heitmann, Stefan, Aringer, Martin ORCID: 0000-0003-4471-8375, Fischer-Betz, Rebecca, Doerner, Thomas and Tony, Hans-Peter (2012). Efficacy and Safety of Rituximab Treatment in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitides: Results from a German Registry (GRAID). J. Rheumatol., 39 (11). S. 2153 - 2157. TORONTO: J RHEUMATOL PUBL CO. ISSN 0315-162X

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Abstract

Objective. Rituximab (RTX) therapy is a treatment option in patients with refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We investigated the tolerability and clinical efficacy of RTX in a cohort of patients with refractory AAV. Methods. Clinical and safety data of patients with AAV treated with RTX were retrospectively assessed from the data of a German national registry. Results. In total, 58 patients were included in this analysis (50/58 with granulomatosis with polyangiitis; 8/58 with microscopic polyangiitis who received at least I cycle, 17 patients who received 2 cycles, and 3 patients who received 3 cycles of RTX). Response was classified as complete and partial in 22 (40%) and in 29 cases (52.7%), respectively. Four patients (7.3%) were classified as nonresponders. Conclusion. RTX was well tolerated with good clinical efficacy in patients with refractory AAV. (First Release Sept 15 2012; J Rheumatol 2012;39:2153-6; doi:10.3899/jrheum.120482)

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Roll, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ostermeier, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haubitz, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lovric, SvjetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unger, LeonoreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holle, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koetter, InaUNSPECIFIEDorcid.org/0000-0002-9262-005XUNSPECIFIED
Henes, Joerg C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergner, RaoulUNSPECIFIEDorcid.org/0000-0002-7965-1273UNSPECIFIED
Rubbert-Roth, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Specker, ChristofUNSPECIFIEDorcid.org/0000-0003-2504-3229UNSPECIFIED
Schulze-Koops, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller-Ladner, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleck, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burmester, Gerd-RuedigerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hiepe, FalkUNSPECIFIEDorcid.org/0000-0003-3584-5292UNSPECIFIED
Heitmann, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aringer, MartinUNSPECIFIEDorcid.org/0000-0003-4471-8375UNSPECIFIED
Fischer-Betz, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerner, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tony, Hans-PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-479771
DOI: 10.3899/jrheum.120482
Journal or Publication Title: J. Rheumatol.
Volume: 39
Number: 11
Page Range: S. 2153 - 2157
Date: 2012
Publisher: J RHEUMATOL PUBL CO
Place of Publication: TORONTO
ISSN: 0315-162X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
WEGENERS-GRANULOMATOSIS; THERAPY; CYCLOPHOSPHAMIDE; MANIFESTATIONS; EXPERIENCE; DEPLETIONMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/47977

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