Drusan, Michal, Loelsberg, Wibke, Skvorcova, Andrea, Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 and Sebesta, Radovan
ORCID: 0000-0002-7975-3608
(2012).
TADDOL-Based Phosphane-Phosphite Ligands in Enantioselective Cu-Catalyzed Grignard 1,4-Additions Followed by Mannich-Type Alkylations.
Eur. J. Org. Chem., 2012 (31).
S. 6285 - 6291.
WEINHEIM:
WILEY-V C H VERLAG GMBH.
ISSN 1099-0690
Abstract
Copper(I) complexes of TADDOL-based phosphanephosphite ligands catalyze enantioselective conjugate additions of various Grignard reagents to cyclic enones. Through trapping of the resulting chiral magnesium enolates with N-benzylidene-4-methylbenzenesulfonamide (as an imine) in one-pot procedures, the corresponding Mannich products (i.e., beta-aminocarbonyl compounds) were obtained in good yields and high enantiomeric purities, although with only low diastereoselectivities.
Item Type: | Journal Article | ||||||||||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-480451 | ||||||||||||||||||||||||
DOI: | 10.1002/ejoc.201200729 | ||||||||||||||||||||||||
Journal or Publication Title: | Eur. J. Org. Chem. | ||||||||||||||||||||||||
Volume: | 2012 | ||||||||||||||||||||||||
Number: | 31 | ||||||||||||||||||||||||
Page Range: | S. 6285 - 6291 | ||||||||||||||||||||||||
Date: | 2012 | ||||||||||||||||||||||||
Publisher: | WILEY-V C H VERLAG GMBH | ||||||||||||||||||||||||
Place of Publication: | WEINHEIM | ||||||||||||||||||||||||
ISSN: | 1099-0690 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
Uncontrolled Keywords: |
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URI: | http://kups.ub.uni-koeln.de/id/eprint/48045 |
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