Universität zu Köln

Drusan, Michal, Loelsberg, Wibke, Skvorcova, Andrea, Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 and Sebesta, Radovan ORCID: 0000-0002-7975-3608 (2012). TADDOL-Based Phosphane-Phosphite Ligands in Enantioselective Cu-Catalyzed Grignard 1,4-Additions Followed by Mannich-Type Alkylations. Eur. J. Org. Chem., 2012 (31). S. 6285 - 6291. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1099-0690

Full text not available from this repository.

Abstract

Copper(I) complexes of TADDOL-based phosphanephosphite ligands catalyze enantioselective conjugate additions of various Grignard reagents to cyclic enones. Through trapping of the resulting chiral magnesium enolates with N-benzylidene-4-methylbenzenesulfonamide (as an imine) in one-pot procedures, the corresponding Mannich products (i.e., beta-aminocarbonyl compounds) were obtained in good yields and high enantiomeric purities, although with only low diastereoselectivities.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drusan, Michal UNSPECIFIED UNSPECIFIED UNSPECIFIED Loelsberg, Wibke UNSPECIFIED UNSPECIFIED UNSPECIFIED Skvorcova, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED Sebesta, Radovan UNSPECIFIED orcid.org/0000-0002-7975-3608 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-480451
DOI:	10.1002/ejoc.201200729
Journal or Publication Title:	Eur. J. Org. Chem.
Volume:	2012
Number:	31
Page Range:	S. 6285 - 6291
Date:	2012
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1099-0690
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASYMMETRIC CONJUGATE ADDITION; CYCLIC ENONES; REAGENTS Multiple languages Chemistry, Organic Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48045