Universität zu Köln

Renner, Marcus, Czwan, Esteban, Hartmann, Wolfgang ORCID: 0000-0002-7609-5021, Penzel, Roland, Brors, Benedikt ORCID: 0000-0001-5940-3101, Eils, Roland ORCID: 0000-0002-0034-4036, Wardelmann, Eva, Buettner, Reinhard, Lichter, Peter, Schirmacher, Peter and Mechtersheimer, Gunhild (2012). MicroRNA profiling of primary high-grade soft tissue sarcomas. Gene Chromosomes Cancer, 51 (11). S. 982 - 997. HOBOKEN: WILEY. ISSN 1098-2264

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Abstract

High-grade soft tissue sarcomas are a heterogeneous and complex group of tumors. MicroRNAs (miRNAs) are considered as attractive candidates that may improve diagnostic, prognostic, and predictive characterization of this group of malignancies. We performed a comprehensive miRNA expression analysis in a series of 76 untreated, primary high-grade soft tissue sarcomas representing eight subtypes, and in a panel of 15 representative sarcoma cell lines using microarray technology. This screening revealed unique miRNA expression patterns for synovial sarcomas, myxoid liposarcomas, and leiomyosarcomas, and defined unique sets of miRNAs discriminating the different liposarcoma subtypes from non-neoplastic adipose tissue. The over-represented miRNAs included members of the miR-200 family in synovial sarcomas, and the tumor-associated miR-9 and miR-9* in myxoid liposarcomas compared to adipose tissue. Moreover, we found coexpression of 63 miRNAs clustering in a genetically imprinted chromosomal region 14q32.2 separating primary sarcoma samples and sarcoma cell lines into two molecular subgroups. Taken together, our comprehensive miRNA profiling identified a novel set of miRNAs that might contribute to sarcomagenesis and provide a starting point for experimental modulation of relevant targets for new therapeutic strategies in high-grade sarcomas. (c) 2012 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Renner, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Czwan, Esteban UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Wolfgang UNSPECIFIED orcid.org/0000-0002-7609-5021 UNSPECIFIED Penzel, Roland UNSPECIFIED UNSPECIFIED UNSPECIFIED Brors, Benedikt UNSPECIFIED orcid.org/0000-0001-5940-3101 UNSPECIFIED Eils, Roland UNSPECIFIED orcid.org/0000-0002-0034-4036 UNSPECIFIED Wardelmann, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichter, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Schirmacher, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mechtersheimer, Gunhild UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-480502
DOI:	10.1002/gcc.21980
Journal or Publication Title:	Gene Chromosomes Cancer
Volume:	51
Number:	11
Page Range:	S. 982 - 997
Date:	2012
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1098-2264
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MIR-200 FAMILY; E-CADHERIN; CELL-LINE; EXPRESSION; SIGNATURES; ESTABLISHMENT; PLURIPOTENCY; CLUSTER; TUMORS Multiple languages Oncology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48050