Universität zu Köln

Eggers, Carsten, Pedrosa, David J., Kahraman, Deniz, Maier, Franziska, Lewis, Catharine J., Fink, Gereon R. ORCID: 0000-0002-8230-1856, Schmidt, Matthias and Timmermann, Lars (2012). Parkinson Subtypes Progress Differently in Clinical Course and Imaging Pattern. PLoS One, 7 (10). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objective: To elucidate whether Parkinson's disease (PD) subtypes show a differential pattern of FP-CIT-SPECT binding during the disease course. Methods: We examined 27 patients (10 female, 17 male, mean age 61.68 +/- 11.24 years, 14 tremordominant, 13 akineticrigid) with [I-123]FP-CIT-SPECT and clinical ratings including UPDRS III after at baseline and after a mean period of 2.47 years. Patients had been classified at baseline as tremordominant or akinetic-rigid according to a tremor score'' and non-tremor score''. These subgroups were compared for differences in disease progression. Means of clinical ratings and the quantitative analyses of FP-CIT-SPECT for ipsi- and contralateral putamen and caudate nucleus were calculated and compared between baseline and follow-up. Results: There were no statistical differences concerning age, disease duration, L-Dopa equivalent dose, disease severity (UPDRS III) or dopaminergic uptake in FP-CIT-SPECT at baseline between both subgroups. At follow-up, akinetic-rigid patients showed a distinct and statistically significant reduction of the dopaminergic uptake associated with significant progression of the clinical symptoms (UPDRS III). In contrast, in tremor patients the aggravation of clinical symptoms and dopaminergic deficit was less pronounced without statistical significance among assessments. Conclusions: This study shows for the first time a considerable progression of clinical symptoms and in-vivo dopaminergic deficit of akinetic-rigid compared to tremordominant PD patients over time. Our data may help to improve strategic planning of further therapeutic trials and to provide a clearer prognosis for patients regarding the perspective of their disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Pedrosa, David J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kahraman, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewis, Catharine J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481118
DOI:	10.1371/journal.pone.0046813
Journal or Publication Title:	PLoS One
Volume:	7
Number:	10
Date:	2012
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DOPAMINE TRANSPORTER; DISEASE SUBTYPES; DECLINE; TREMOR; SPECT; PET; HETEROGENEITY; DEGENERATION; ASSOCIATION; DEMENTIA Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48111