Kueppers, Ralf, Engert, Andreas and Hansmann, Martin-Leo (2012). Hodgkin lymphoma. J. Clin. Invest., 122 (10). S. 3439 - 3448. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

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Abstract

Hodgkin lymphoma (HL), a B cell-derived cancer, is one of the most common lymphomas. In HL, the tumor cells - Hodgkin and Reed-Sternberg (HRS) cells - are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvirmunent, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-kappa B and JAK/STAT pathways are frequent. The dependency of HRS cells on tnicroenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kueppers, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansmann, Martin-LeoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-481724
DOI: 10.1172/JCI6124.5
Journal or Publication Title: J. Clin. Invest.
Volume: 122
Number: 10
Page Range: S. 3439 - 3448
Date: 2012
Publisher: AMER SOC CLINICAL INVESTIGATION INC
Place of Publication: ANN ARBOR
ISSN: 1558-8238
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REED-STERNBERG CELLS; EPSTEIN-BARR-VIRUS; KAPPA-B-ALPHA; IMMUNOGLOBULIN GENE REARRANGEMENTS; POSITRON-EMISSION-TOMOGRAPHY; EXTENDED-FIELD RADIOTHERAPY; TUMOR-SUPPRESSOR GENE; CLASSICAL HODGKIN; SIDE-POPULATION; REED/STERNBERG-CELLSMultiple languages
Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48172

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