Universität zu Köln

Jung, N., Kuemmerle, T., Brengelmann, S. D., Gielen, J., Lehmann, C., Wyen, C., Birtel, A., Fischer, J., Gillor, D., Koch, S., Vehreschild, J. J., Cornely, O. A. and Faetkenheuer, G. (2012). Liver involvement in HIV-infected patients diagnosed with syphilis. Infection, 40 (5). S. 543 - 548. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Liver involvement in syphilis has been studied in cohorts of human immunodeficiency virus (HIV)-negative individuals despite the scarcity of data on such HIV-infected patients. Th aim of this study was to assess hepatic involvement of HIV-infected patients diagnosed with syphilis. Patients with syphilis and liver involvement, including all stages of syphilis, were systematically identified in our HIV cohort between 2004 and 2008. Of the 1,599 HIV-infected patients identified during the study period, 100 were diagnosed with acute syphilis, all of whom were male. Of these 100 patients, 84 % were men who have sex with men. Laboratory parameters of liver involvement were present in 19 of the 100 HIV-infected patients with syphilis; these resolved after successful antibiotic treatment. Among these 19 patients, six were diagnosed to be in the latent stage, with elevated liver enzymes and parameters of inflammation representing the only distinctive feature. Based on our results, syphilis should be included in the differential diagnosis of increased liver enzymes in HIV-infected patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jung, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuemmerle, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brengelmann, S. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gielen, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wyen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Birtel, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gillor, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vehreschild, J. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481903
DOI:	10.1007/s15010-012-0264-3
Journal or Publication Title:	Infection
Volume:	40
Number:	5
Page Range:	S. 543 - 548
Date:	2012
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENITAL ULCER DISEASE; HEPATITIS; GUIDELINES; EXPRESSION Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48190