Universität zu Köln

Nast, Alexander ORCID: 0000-0003-3504-2203, Eming, Sabine, Fluhr, Joachim, Fritz, Klaus, Gauglitz, Gerd, Hohenleutner, Silvia, Panizzon, Renato G., Sebastian, Guenther, Sporbeck, Birte and Koller, Josef (2012). Efficacy and safety of rituximab in pemphigus: experience of the German Registry of Autoimmune Diseases. J. Dtsch. Dermatol. Ges., 10 (10). S. 747 - 763. HOBOKEN: WILEY. ISSN 1610-0387

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Abstract

Background: Rituximab has been reported to be effective in various small case series of patients with severe and/or refractory pemphigus. However, no systematic evaluation is available to corroborate this observation. The aim of this study was to systematically determine efficacy and safety of rituximab in treatment-resistant pemphigus. Patients and Methods: Multicenter retrospective, observational study of 36 patients with severe pemphigus vulgaris (n = 33) and pemphigus foliaceus (n = 3) treated with rituximab before August 31st, 2008 and enrolled in a national observational registery between December 2008 and June 2009. Results: Within a mean period of observation of 11 (137) months, 21 (58 %) pemphigus patients showed complete, 13 (36 %) partial, and 2 (6 %) no response to rituximab treatment. This correlates with a mean improvement of the visual analog scale for well-being of 34 (2060) at baseline to 75 (4095) at the last control visit. In 4 (11 %) patients, severe adverse events were recorded including 1 (3 %) serious infection. Conclusions: Data collected in this systematic registry indicate that rituximab is an effective and relatively safe adjuvant treatment option for refractory pemphigus. To further extend our knowledge on efficacy and safety of this drug, controlled prospective trials are required.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nast, Alexander UNSPECIFIED orcid.org/0000-0003-3504-2203 UNSPECIFIED Eming, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Fluhr, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritz, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Gauglitz, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohenleutner, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Panizzon, Renato G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sebastian, Guenther UNSPECIFIED UNSPECIFIED UNSPECIFIED Sporbeck, Birte UNSPECIFIED UNSPECIFIED UNSPECIFIED Koller, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481944
DOI:	10.1111/j.1610-0387.2012.08012.x
Journal or Publication Title:	J. Dtsch. Dermatol. Ges.
Volume:	10
Number:	10
Page Range:	S. 747 - 763
Date:	2012
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1610-0387
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROTEIN-A IMMUNOADSORPTION; RHEUMATOID-ARTHRITIS; ADJUVANT TREATMENT; SKIN DISEASES; VULGARIS; THERAPY Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48194