Universität zu Köln

Brunn, Anna, Zornbach, Katja, Hans, Volkmar H., Haupt, Walter F. and Deckert, Martina (2012). Toll-Like Receptors Promote Inflammation in Idiopathic Inflammatory Myopathies. J. Neuropathol. Exp. Neurol., 71 (10). S. 855 - 868. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 0022-3069

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Abstract

The roles of Toll-like receptors (TLRs) and their myeloid differentiation response gene 88 (MyD88)-dependent and MyD88-independent signaling cascade particularly with regard to the pathogenesis and regulation of immune responses in idiopathic inflammatory myopathies are unclear. We investigated these pathways in muscle biopsies from 5 cases each of polymyositis, inclusion body myositis, dermatomyositis, vasculitis-associated interstitial myositis, and noninflammatory neurogenic atrophy. Toll-like receptor 2, TLR4, TLR9, and MyD88 mRNA transcripts and protein expression were increased in all subtypes of idiopathic inflammatory myopathies. Upregulation of MyD88 was associated with increased mRNA levels of interferon-gamma, interleukin 12p40, and interleukin 17, suggesting NF-kappa B activation via the MyD88-dependent pathway in early stages. The costimulatory molecules CD80 and CD86 were expressed on inflammatory infiltrates in idiopathic inflammatory myopathies and may additionally contribute to activation of the MyD88-independent pathway, leading to nuclear factor-kappa B activation in late stages. Our data suggest that nuclear factor-kappa B activation via both the MyD88-dependent and the MyD88-independent pathways contributes to the proinflammatory milieu in idiopathic inflammatory myopathies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brunn, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Zornbach, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Hans, Volkmar H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haupt, Walter F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Deckert, Martina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-481958
DOI:	10.1097/NEN.0b013e31826bf7f3
Journal or Publication Title:	J. Neuropathol. Exp. Neurol.
Volume:	71
Number:	10
Page Range:	S. 855 - 868
Date:	2012
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	0022-3069
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PERIPHERAL-BLOOD LYMPHOCYTES; CENTRAL-NERVOUS-SYSTEM; KAPPA-B ACTIVATION; INNATE IMMUNITY; DENDRITIC CELLS; SCHWANN-CELL; CUTTING EDGE; T-CELLS; EXPRESSION Multiple languages Clinical Neurology; Neurosciences; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48195