Seemueller, Florian, Schennach, Rebecca, Mayr, Andreas ORCID: 0000-0001-7106-9732, Musil, Richard ORCID: 0000-0002-0792-8413, Jaeger, Markus, Maier, Wolfgang, Klingenberg, Stefan, Heuser, Isabella, Klosterkoetter, Joachim, Gastpar, Markus, Schmitt, Andrea ORCID: 0000-0002-5426-4023, Schloesser, Ralf, Schneider, Frank ORCID: 0000-0003-1557-7956, Ohmann, Christian, Lewitzka, Ute, Gaebel, Wolfgang, Moeller, Hans-Juergen and Riedel, Michael (2012). Akathisia and Suicidal Ideation in First-Episode Schizophrenia. J. Clin. Psychopharmacol., 32 (5). S. 694 - 699. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1533-712X

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Abstract

Patients with first-episode schizophrenia (FES) are known to be notably sensitive for developing extrapyramidal adverse effects, but the relation of akathisia and suicidal ideation has rarely been studied. The current report is an ongoing analysis of an 8-week double-blind randomized controlled multicenter trial in 289 FES, comparing risperidone and haloperidol. Assessments were conducted weekly and included the Hillside Akathisia Scale and 21-item Hamilton Depression Rating Scale ratings. Suicidal ideation was significantly associated with clinician observed akathisia, depressed mood, younger age, and use of propranolol. The allocated treatment, anxiety, and nervousness had no influence. The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Seemueller, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schennach, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayr, AndreasUNSPECIFIEDorcid.org/0000-0001-7106-9732UNSPECIFIED
Musil, RichardUNSPECIFIEDorcid.org/0000-0002-0792-8413UNSPECIFIED
Jaeger, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingenberg, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heuser, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gastpar, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, AndreaUNSPECIFIEDorcid.org/0000-0002-5426-4023UNSPECIFIED
Schloesser, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, FrankUNSPECIFIEDorcid.org/0000-0003-1557-7956UNSPECIFIED
Ohmann, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewitzka, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, Hans-JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-482120
DOI: 10.1097/JCP.0b013e3182677958
Journal or Publication Title: J. Clin. Psychopharmacol.
Volume: 32
Number: 5
Page Range: S. 694 - 699
Date: 2012
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1533-712X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BIOLOGICAL-PSYCHIATRY WFSBP; WORLD-FEDERATION; TERM TREATMENT; TRIAL; SCALE; HALOPERIDOL; ASSOCIATION; RISPERIDONE; GUIDELINES; SOCIETIESMultiple languages
Pharmacology & Pharmacy; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/48212

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