Universität zu Köln

Schmitt, Jana, Keller, Andreas, Nourkami-Tutdibi, Nasenien, Heisel, Sabrina, Habel, Nunja, Leidinger, Petra, Ludwig, Nicole, Gessler, Manfred ORCID: 0000-0002-7915-6045, Graf, Norbert ORCID: 0000-0002-2248-323X, Berthold, Frank, Lenhof, Hans-Peter and Meese, Eckart (2011). Autoantibody Signature Differentiates Wilms Tumor Patients from Neuroblastoma Patients. PLoS One, 6 (12). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Several studies report autoantibody signatures in cancer. The majority of these studies analyzed adult tumors and compared the seroreactivity pattern of tumor patients with the pattern in healthy controls. Here, we compared the autoimmune response in patients with neuroblastoma and patients with Wilms tumor representing two different childhood tumors. We were able to differentiate untreated neuroblastoma patients from untreated Wilms tumor patients with an accuracy of 86.8%, a sensitivity of 87.0% and a specificity of 86.7%. The separation of treated neuroblastoma patients from treated Wilms tumor patients' yielded comparable results with an accuracy of 83.8%. We furthermore identified the antigens that contribute most to the differentiation between both tumor types. The analysis of these antigens revealed that neuroblastoma was considerably more immunogenic than Wilms tumor. The reported antigens have not been found to be relevant for comparative analyses between other tumors and controls. In summary, neuroblastoma appears as a highly immunogenic tumor as demonstrated by the extended number of antigens that separate this tumor from Wilms tumor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmitt, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Keller, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Nourkami-Tutdibi, Nasenien UNSPECIFIED UNSPECIFIED UNSPECIFIED Heisel, Sabrina UNSPECIFIED UNSPECIFIED UNSPECIFIED Habel, Nunja UNSPECIFIED UNSPECIFIED UNSPECIFIED Leidinger, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Ludwig, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Gessler, Manfred UNSPECIFIED orcid.org/0000-0002-7915-6045 UNSPECIFIED Graf, Norbert UNSPECIFIED orcid.org/0000-0002-2248-323X UNSPECIFIED Berthold, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenhof, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Meese, Eckart UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-483331
DOI:	10.1371/journal.pone.0028951
Journal or Publication Title:	PLoS One
Volume:	6
Number:	12
Date:	2011
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPARAN-SULFATE; N-MYC; SERUM AUTOANTIBODIES; SUPPRESSORS EXT1; NEURO-BLASTOMA; ALLELIC LOSS; LUNG-CANCER; CHILDREN; AMPLIFICATION; THERAPY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48333