Universität zu Köln

Cremer, Birgit, Sandmaier, Brenda M., Bethge, Wolfgang, Lange, Thoralf, Goede, Valentin, Holtick, Udo, Hallek, Michael and Huebel, Kai (2011). Reduced-Intensity Conditioning in Allogeneic Stem Cell Transplantation for Hematological Malignancies: A Historical Perspective. Onkologie, 34 (12). S. 710 - 716. BASEL: KARGER. ISSN 1423-0240

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Abstract

Allogeneic hematopoietic stem cell transplantation represents a curative treatment approach for a large range of hematologic malignancies. Traditionally, high-dose radiochemotherapy as preparative regimen has been thought to be necessary for successful allogeneic stem cell transplantation. However, high-dose conditioning often results in considerable medullary and extramedullary toxicity, contributing to high rates of treatment-related mortality. This limits the use of this procedure to patients below 60 years of age without significant comorbidities. Since the peak incidence of most hematological malignancies is beyond the 5th decade of life, the majority of patients are not eligible for high-dose treatment. During the last 15 years, several dose-reduced or even non-myeloablative conditioning regimens have been developed, offering a curative treatment option for these patients. This review summarizes the history of reduced-intensity conditioning (RIC) transplantations, depicts the differences among regimens, highlights significant patient factors, and describes the impact on selected hematological malignancies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cremer, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandmaier, Brenda M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bethge, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Thoralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Goede, Valentin UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtick, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484181
DOI:	10.1159/000334542
Journal or Publication Title:	Onkologie
Volume:	34
Number:	12
Page Range:	S. 710 - 716
Date:	2011
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0240
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHRONIC LYMPHOCYTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; RELAPSED FOLLICULAR LYMPHOMA; MINIMAL RESIDUAL DISEASE; VERSUS-HOST-DISEASE; MULTIPLE-MYELOMA; HODGKINS-LYMPHOMA; PREPARATIVE REGIMENS; SALVAGE TREATMENT; GRAFT Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48418