Universität zu Köln

Batoulis, Helena, Recks, Mascha S., Addicks, Klaus and Kuerten, Stefanie (2011). Experimental autoimmune encephalomyelitis - achievements and prospective advances. APMIS, 119 (12). S. 819 - 831. MALDEN: WILEY-BLACKWELL. ISSN 0903-4641

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Abstract

Multiple sclerosis (MS) is an autoimmune disorder of the CNS. Different subtypes of the disease have been noted, and characterized by distinct clinical courses and histopathologic manifestations. The most intensively studied animal model of MS, experimental autoimmune encephalomyelitis (EAE), classically leads to deficits in motor functions, and is mediated by T helper cells. Recently, T(H)17 cells were ascribed an even greater pathogenic impact than T(H)1 cells, but new findings render this view controversial. Although classic EAE has been an invaluable tool, it does not cover the entire pathogenic entity of MS. Especially B-cell contribution and autoantibody-dependence are not mirrored adequately: therefore, new B-cell-dependent models, such as MP4-induced EAE, have been introduced. Furthermore, certain symptoms and the spontaneous onset of MS are not featured in classic EAE. Herein, atypical and spontaneous EAE models can be used for investigation of common symptoms, such as tremor and ataxia, as well as spontaneous disease development. MS displays a marked inter-individual heterogeneity, and no single model will be able to cover all features. Thus, depending on the objective of one's study, the appropriate EAE model has to be carefully chosen. In addition, refined models should be designed to gain a more complete understanding of MS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Batoulis, Helena UNSPECIFIED UNSPECIFIED UNSPECIFIED Recks, Mascha S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484678
DOI:	10.1111/j.1600-0463.2011.02794.x
Journal or Publication Title:	APMIS
Volume:	119
Number:	12
Page Range:	S. 819 - 831
Date:	2011
Publisher:	WILEY-BLACKWELL
Place of Publication:	MALDEN
ISSN:	0903-4641
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Immunology; Microbiology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48467