Universität zu Köln

Kuerten, Stefanie and Lehmann, Paul V. (2011). The Immune Pathogenesis of Experimental Autoimmune Encephalomyelitis: Lessons Learned for Multiple Sclerosis? J. Interferon Cytokine Res., 31 (12). S. 907 - 917. NEW ROCHELLE: MARY ANN LIEBERT INC. ISSN 1079-9907

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Abstract

Experimental autoimmune encephalomyelits (EAE) has been widely studied as a model for multiple sclerosis (MS). EAE also holds a special place in basic autoimmune research. It is induced by immunizing healthy, naive mice with neuroantigen. Unlike in spontaneous autoimmune models, one can therefore clearly define the initiation time point, the inducing antigen, the circumstances of the immunization that elicit a pathogenic-or nonpathogenic-T cell response, and many other parameters that are required for the induction and perpetuation of autoimmune central nervous system pathology. In the following, we will provide an overview of our current understanding of the discrete steps that lead to the pathogenesis of EAE, and we will highlight several junctions at which the perpetuation or abortive course of the disease is defined. It has become abundantly clear that the induction of a pathogenic CD4(+) T cell response is a necessary requirement for the induction of EAE. However, many downstream mechanisms need to be considered if we want to understand the pathomechanisms that define the variable outcomes of EAE, and by inference, of MS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Paul V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-484869
DOI:	10.1089/jir.2011.0072
Journal or Publication Title:	J. Interferon Cytokine Res.
Volume:	31
Number:	12
Page Range:	S. 907 - 917
Date:	2011
Publisher:	MARY ANN LIEBERT INC
Place of Publication:	NEW ROCHELLE
ISSN:	1079-9907
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; INCOMPLETE FREUNDS-ADJUVANT; T-CELL REPERTOIRE; C57BL/6 MICE; PERTUSSIS TOXIN; HIGH-FREQUENCIES; B-CELLS; EAE Multiple languages Biochemistry & Molecular Biology; Cell Biology; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48486