Universität zu Köln

Sierra, Saleta, Luebke, Nadine, Walter, Hauke, Schuelter, Eugen, Reuter, Stefan, Faetkenheuer, Gerd, Bickel, Markus, da Silva, Hugo, Kaiser, Rolf and Esser, Stefan (2011). The SnoB study: frequency of baseline raltegravir resistance mutations prevalence in different non-B subtypes. Med. Microbiol. Immunol., 200 (4). S. 225 - 233. NEW YORK: SPRINGER. ISSN 1432-1831

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Abstract

The SnoB study analysed the variability of the integrase (IN) gene of non-B viruses from treatment-naive patients to determine whether non-B subtypes carry natural resistance mutations to raltegravir (RAL). Plasma viral RNA from 427 patients was gained, and IN sequences were subtyped and screened for subtype-specific highly-variable residues. Seven viruses of different subtypes were phenotypically tested for RAL susceptibility; 359/427 samples could be sequenced. One hundred and seventy samples (47%) were classified as non-B subtypes. No primary RAL resistance-associated mutations (RRAMs) were detected. Certain secondary mutations were found, mostly related to specific non-B subtypes. L74 M was significantly more prevalent in subtype 02_AG, T97A in A and 06_cpx, V151I in 06_cpx, and G163R in 12_BF. Various additional mutations were also detected and could be associated with the subtype too. While K156 N and S230 N were correlated with B subtype, V72I, L74I, T112I, T125A, V201I and T206S were more frequent in certain non-B subtypes. The resistance factors (RF) of 7 viral strains of different subtypes ranged from 1.0 to 1.9. No primary or secondary but subtype-associated additional RRAMs were present. No correlation between RF and additional RRAMs was found. The prevalence of RRAMs was higher in non-B samples. However, the RFs for the analysed non-B subtypes showed lower values to those reported relevant to clinical failure. As the role of baseline secondary and additional mutations on RAL therapy failure is actually not known, baseline IN screening is necessary.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sierra, Saleta UNSPECIFIED UNSPECIFIED UNSPECIFIED Luebke, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Walter, Hauke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuelter, Eugen UNSPECIFIED UNSPECIFIED UNSPECIFIED Reuter, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Faetkenheuer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED da Silva, Hugo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Esser, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-485638
DOI:	10.1007/s00430-011-0194-1
Journal or Publication Title:	Med. Microbiol. Immunol.
Volume:	200
Number:	4
Page Range:	S. 225 - 233
Date:	2011
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1831
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIV-1 INTEGRASE; TREATMENT-NAIVE; INHIBITOR; PHARMACOKINETICS; ELVITEGRAVIR Multiple languages Immunology; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48563