Universität zu Köln

Kuhn, J., Bodatsch, M., Sturm, V., Lenartz, D., Klosterkoetter, J., Uhlhaas, P. J., Winter, C. and Gruendler, T. O. J. (2011). Deep Brain Stimulation in Schizophrenia. Forschritte Neurol. Psychiatr., 79 (11). S. 632 - 642. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

Deep brain stimulation (DBS) has successfully advanced our treatment options for putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation, more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially, schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. This attention demands critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed pathophysiology of schizophrenia. Here, we synoptically compare current approaches and theories of DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic transmission as well as data concerning neural oscillation and synchronisation. In conclusion, the use of DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might hinder the use of DBS for schizophrenia at this point in time.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuhn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bodatsch, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sturm, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenartz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhlhaas, P. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Winter, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruendler, T. O. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-485873
DOI:	10.1055/s-0031-1281733
Journal or Publication Title:	Forschritte Neurol. Psychiatr.
Volume:	79
Number:	11
Page Range:	S. 632 - 642
Date:	2011
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3522
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGH-FREQUENCY STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; NIGRA PARS RETICULATA; STRIATAL DOPAMINERGIC METABOLISM; INDUCED COMPULSIVE CHECKING; SUBTHALAMIC NUCLEUS; GLOBUS-PALLIDUS; PSYCHIATRIC-DISORDERS; PARKINSONS-DISEASE; FOLLOW-UP Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48587