Universität zu Köln

Belavy, Daniel L., Bansmann, P. Martin, Boehme, Gisela, Frings-Meuthen, Petra, Heer, Martina ORCID: 0000-0001-5534-911X, Rittweger, Joern, Zange, Jochen and Felsenberg, Dieter (2011). Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest. J. Appl. Physiol., 111 (5). S. 1304 - 1315. BETHESDA: AMER PHYSIOLOGICAL SOC. ISSN 1522-1601

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Abstract

Belavy DL, Bansmann PM, Bohme G, Frings-Meuthen P, Heer M, Rittweger J, Zange J, Felsenberg D. Changes in intervertebral disc morphology persist 5 mo after 21-day bed rest. J Appl Physiol 111: 1304-1314, 2011. First published July 28, 2011; doi:10.1152/japplphysiol.00695.2011.-As part of the nutrition-countermeasures (NUC) study in Cologne, Germany in 2010, seven healthy male subjects underwent 21 days of head-down tilt bed rest and returned 153 days later to undergo a second bout of 21-day bed rest. As part of this model, we aimed to examine the recovery of the lumbar intervertebral discs and muscle cross-sectional area (CSA) after bed rest using magnetic resonance imaging and conduct a pilot study on the effects of bed rest in lumbar muscle activation, as measured by signal intensity changes in T-2-weighted images after a standardized isometric spinal extension loading task. The changes in intervertebral disc volume, anterior and posterior disc height, and intervertebral length seen after bed rest did not return to prebed-rest values 153 days later. While recovery of muscle CSA occurred after bed rest, increases (P <= 0.016) in multifidus, psoas, and quadratus lumborum muscle CSA were seen 153 days after bed rest. A trend was seen for greater activation of the erector spinae and multifidus muscles in the standardized loading task after bed rest. Greater reductions of multifidus and psoas CSA muscle and greater increases in multifidus signal intensity with loading were associated with incidence of low back pain in the first 28 days after bed rest (P <= 0.044). The current study contributes to our understanding of the recovery of the lumbar spine after 21-day bed rest, and the main finding was that a decrease in spinal extensor muscle CSA recovers within 5 mo after bed rest but that changes in the intervertebral discs persist.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Belavy, Daniel L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bansmann, P. Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Boehme, Gisela UNSPECIFIED UNSPECIFIED UNSPECIFIED Frings-Meuthen, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Heer, Martina UNSPECIFIED orcid.org/0000-0001-5534-911X UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Zange, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Felsenberg, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-485898
DOI:	10.1152/japplphysiol.00695.2011
Journal or Publication Title:	J. Appl. Physiol.
Volume:	111
Number:	5
Page Range:	S. 1304 - 1315
Date:	2011
Publisher:	AMER PHYSIOLOGICAL SOC
Place of Publication:	BETHESDA
ISSN:	1522-1601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CROSS-SECTIONAL AREA; LUMBAR SPINE; STABILIZING SYSTEM; KNEE-EXTENSOR; HEIGHT AFFECT; EXERCISE; COUNTERMEASURES; PROTEOGLYCANS; RACEMIZATION; DYSFUNCTION Multiple languages Physiology; Sport Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/48589